PMID: 7515069Jun 1, 1994Paper

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent

The Journal of Cell Biology
A M Romanic, J A Madri

Abstract

T cell extravasation from the bloodstream into the perivascular tissue during inflammation involves transmigration through the endothelial cell layer and basement membrane into the interstitial matrix. The specific mechanisms by which T cells transmigrate, however, are poorly understood. Matrix degradation by enzymes such as 72-kD gelatinase has been implicated as an important component in tissue invasion by various types of cells. In this study, we have demonstrated that 72-kD gelatinase is induced in T cells upon adhesion to endothelial cells. We also provide evidence that the induction of 72-kD gelatinase is mediated by binding to vascular cell adhesion molecule-1 (VCAM-1). The T cells used in this study were cloned murine Th1 cells antigenic to myelin basic protein. These cells express very late antigen-4 on their cell surface and have been shown to infiltrate the brain parenchyma and cause experimental autoimmune encephalomyelitis when infused into normal mice (Baron, J. L., J. A. Madri, N. H. Ruddle, G. Hashim, and C. A. Janeway. 1993. J. Exp. Med. 177:57-68). In the experiments presented here, T cells were cocultured with VCAM-1-positive and -negative endothelial cells grown in a monolayer in order to study the expressio...Continue Reading

References

May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L A LiottaG R Martin
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R E SeftorM J Hendrix
Apr 1, 1992·The Journal of Experimental Medicine·Y NojimaC Morimoto
Jun 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K Takahasi, Y Sawasaki
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A SchwartzD E Ingber
Aug 1, 1991·Experimental Cell Research·J Ng-SikorskiT Andersson
Mar 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K TakahashiT Goto
Aug 15, 1991·Biochemical and Biophysical Research Communications·R LobbI Dougas
Aug 1, 1991·The Journal of Clinical Investigation·A LaffónF Sánchez-Madrid
Aug 2, 1990·Nature·T A Springer
Apr 1, 1990·The Journal of Cell Biology·S M AlbeldaC A Buck
Feb 1, 1986·The Journal of Clinical Investigation·J M DayerC A Dinarello
Apr 1, 1987·The Journal of Cell Biology·F BlasiK Danø
Jul 1, 1983·The Journal of Cell Biology·J A Madri, S K Williams
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Oct 1, 1993·Current Opinion in Cell Biology·D E Kleiner, W G Stetler-Stevenson
Feb 1, 1993·The Journal of Cell Biology·R L Juliano, S Haskill
Nov 20, 2009·Electrophoresis·Dawid R Zalewski, Han J G E Gardeniers

❮ Previous
Next ❯

Citations

Apr 1, 1996·Journal of Cellular Biochemistry·D L WebbM L Blue
May 16, 2001·Arthritis and Rheumatism·R A Carter, I P Wicks
Dec 1, 1996·Annals of Neurology·H P Hartung, B C Kieseier
Dec 14, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Karin EdsparrPer Albertsson
Nov 15, 2002·Molecular Immunology·Joan M Cook-Mills
May 20, 1997·Brain Research. Developmental Brain Research·L R MentJ A Madri
Mar 1, 2000·Journal of Neuroimmunology·A Bar-OrD A Hafler
Oct 1, 1996·Current Opinion in Cell Biology·D DunonB A Imhof
Apr 3, 2001·Trends in Cardiovascular Medicine·S LiuM H Ginsberg
Sep 28, 2001·Trends in Immunology·G OpdenakkerJ Van Damme
Sep 18, 2002·Immunological Reviews·Sirid-Aimée KellermannYoji Shimizu
Sep 18, 2002·Immunological Reviews·Grazisa RossettiRuggero Pardi
Dec 22, 2005·Nature Immunology·Andrew D LusterUlrich H von Andrian
Mar 2, 1999·British Journal of Haematology·G P KaushalT Kelly
Nov 20, 1998·Clinical and Experimental Immunology·C P DentonJ D Pearson
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T T LuJ A Madri
Jun 1, 1995·Molecular Biology of the Cell·P D KassnerM E Hemler
Mar 19, 2004·Biology of Reproduction·S CampbellE D M Gallery
Nov 13, 1998·Current Opinion in Lipidology·S J George
Oct 31, 1996·Annals of the New York Academy of Sciences·R R LobbR B Pepinsky
Nov 18, 1996·Annals of the New York Academy of Sciences·R W Thompson, W C Parks
Jun 18, 1998·Annals of the New York Academy of Sciences·E J GoetzlS P Sreedharan
Nov 20, 2008·Pigment Cell & Melanoma Research·Yannève RollandRichard Béliveau
Feb 28, 2002·The British Journal of Ophthalmology·C CuelloN Di Girolamo
Jan 1, 1995·Mediators of Inflammation·S HoriguchiK Tasaka
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·M SugaM Ando
Nov 1, 1994·The Journal of Clinical Investigation·R R Lobb, M E Hemler
Sep 1, 1996·The Journal of Clinical Investigation·E BianchiR Pardi

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