The induction of B cells refractory to antibody-specific immunoregulation

European Journal of Immunology
N A Speck, S K Pierce

Abstract

Subsequent to primary immunization with a hapten-carrier conjugate, and concomitant with an initial antibody response to that antigen, a regulatory mechanism is induced that specifically limits the stimulation of hapten-specific primary B cell responses through the recognition of B cell antibody. Nonimmune B cells are sensitive to this regulation, while secondary B cells are refractory to its suppressive effects. Experiments were conducted to determine the conditions under which refractory B cell populations are generated. B cells from BALB/c and athymic BALB/c nu/nu mice were examined following immunization with the T-dependent antigen dinitrophenylated (DNP) hemocyanin and the T-independent antigen DNP-Ficoll to assess the T cell dependence of the generation of refractory B cells. Evidence is presented that this process is not dependent on the presence or participation of T cells during in vivo immunization, since both T-dependent and T-independent antigens have the potential to induce a refractory B cell population. However, under certain circumstances, T cells can regulate the induction of refractory B cells during in vivo immunization. In addition, it was determined that the immunoregulatory phenomenon can be induced follo...Continue Reading

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P A Cazenave
Aug 1, 1977·The Journal of Experimental Medicine·S K Pierce, N R Klinman
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Aug 1, 1981·The Journal of Experimental Medicine·N R Klinman
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Citations

Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M L JelachichS K Pierce
Jan 1, 1983·Annals of the New York Academy of Sciences·S K Pierce, N A Speck
Nov 1, 1982·European Journal of Immunology·N A Speck, S K Pierce

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