PMID: 6406216Jan 1, 1983Paper

The induction of chromosome aberrations by cis-platinum(II) diamminodichloride in Drosophila melanogaster

Environmental Mutagenesis
R K BrodbergR C Woodruff

Abstract

We have determined the in vivo effects of cis-platinum(II)diamminodichloride (cis-PDD) treatment on the induction of chromosome aberrations in Drosophila melanogaster germ cells. cis-PDD treatment induces significant increases in chromosome breakage in all stages of spermatogenesis in a battery of test systems using ring or rod-X males and repair-proficient or deficient females. Since no increase in nondisjunction was induced by cis-PDD in either male or female germ cells, any aneuploidy inducing effects of this compound should result from its clastogenic action. We also find that mei-9 excision repair function is involved in the repair of cis-PDD-induced DNA lesions in a manner that provides additional evidence that partial and ring chromosome losses are not completely homologous.

References

Jun 1, 1977·Annals of Internal Medicine·M RozencweigF M Muggia
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Citations

Jun 1, 1990·Mutation Research·M A KatohW M Generoso
Jan 1, 1986·Mutation Research·S ZimmeringC Osgood
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H HannemanJ C Schimenti
May 2, 2000·Journal of Chemotherapy·R C ChoudhuryS Misra
Jan 1, 1987·Environmental and Molecular Mutagenesis·A J Katz

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