PMID: 6968306Jul 1, 1980Paper

The induction of chromosome aberrations in human lymphocytes by alpha-radiation

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
A A EdwardsD C Lloyd

Abstract

Human blood has been irradiated with alpha-particles from an external source of curium-242. The collimated alpha-particles entered the blood with an energy of 4-9 MeV and were almost completely absorbed by the blood. After culturing for 48 hours, the dicentric yield in the lymphocytes at the first metaphase was measured as a function of dose to the blood. The yield was linear with dose up to 400 rad with a slope of 28x6 X 10(4) dicentrics/cell per rad. This is equivalent to an initial slope r.b.e. of 17x9 with respect to cobalt-60 gamma-rays. This value disagrees with the only two other published values in the literature. Reasons for this disagreement are discussed. Compared with neutron r.b.e values obtained in this laboratory the alpha-particle values we observe are surprisingly low. A model is proposed which predicts low values of r.b.e. for chromosome aberration production using radiations of high LET. The low values occur because there is a distribution of specific energy between cells which causes a selective removal of cells likely to contain higher numbers of aberrations.

References

Jul 29, 1977·Radiation and Environmental Biophysics·A A Edwards

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Citations

Sep 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R J PurrottJ W Stather
Nov 15, 2003·Annals of the ICRP·UNKNOWN Task Group on Radiation Quality Effects in Radiological Protection, Committee 1 on Radiation Effects, International Commissi
Apr 25, 2012·Radiation and Environmental Biophysics·Elina StaafAndrzej Wojcik
Jul 28, 2016·International Journal of Radiation Biology·Roser PuigJoan-Francesc Barquinero
Nov 6, 2012·Genome Integrity·Elina StaafAndrzej Wojcik
Mar 22, 2012·Radiation Protection Dosimetry·Elina StaafAndrzej Wojcik
Nov 1, 1981·Physics in Medicine and Biology·G ScarpaG Vulpis
Apr 13, 2017·CMAJ Open·Fintan K T StanleyAaron A Goodarzi
Sep 11, 2020·International Journal of Radiation Biology·Robert StainforthVinita Chauhan
Jan 5, 2021·International Journal of Radiation Biology·Magdalena PłódowskaAndrzej Wojcik
Jan 1, 1991·Pharmacology & Therapeutics·M C EliaM O Bradley
Apr 25, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Fredrik KalholmNiels Bassler
Aug 1, 2021·International Journal of Radiation Biology·Zacharenia NikitakiAlexandros G Georgakilas

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