PMID: 8733173Apr 1, 1996Paper

The induction of counter-interactions in tumor cells as a basis for the development of a therapy

Medical Hypotheses
Z Douvlis


A tumor cell in a stringent situation is under the influence of two, opposite vectorial 'forces'. Resulting from the stringent situation, one of these 'forces' acts as an inhibitor of the synthesis process, whilst the perpetuation of the genetic induction of synthesis processes in the nucleus causes the second 'force' to act in the opposite manner. The influence of these 'forces' results in the formation of a counter interaction which leads to a 'breaking away' or decoupling of interdependent functions which are tuned to each other. This could be characterized as an apospasis and leads to irreversible cell-damage. If there is no decoupling, then there is a differentiation, or loss of the self-renewing capacity. Due to the fact that the counter interaction is inducible in tumor cells with proliferation activities as well as in tumor cells without proliferation activities, cells in both the growth and non-growth fraction can be attacked.


Dec 1, 1978·Pathology, Research and Practice·B Flaks
Jul 15, 1990·International Journal of Cancer. Journal International Du Cancer·J F EliasonF Kaufmann
Feb 1, 1987·The Journal of Cell Biology·D R FinlayD J Forbes
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·J V JohannessenL Pilström
Mar 8, 1984·The New England Journal of Medicine·W C Willett, B MacMahon
Jan 1, 1965·Annual Review of Medicine·B F BOWER, G S GORDAN

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