PMID: 7940719Oct 15, 1994Paper

The induction of immediate early genes in postischemic and transplanted livers in rats. Its relation to organ survival

Transplantation
S GotoP Wilce

Abstract

The protein products of the immediate early genes (IEG)s have been proposed to play an important role in long-term tissue plasticity such as cell repair or programmed cell death. The expression of liver IEGs was studied following liver ischemia (LI) or OLT in rats. In LI, 60 min of warm ischemia was induced in shunted rats (shunt LI group; 100% survival) and nonshunted rats (nonshunted LI group; poor survival). In OLT, donor livers were transplanted into the recipients within 1 hr (fresh liver OLT group; 100% survival) or after 24 hr of storage using University of Wisconsin solution (preserved liver OLT group; poor survival). Using both models, IEG mRNAs (c-fos and c-jun) were analyzed by Northern blot hybridization at various times before and after reperfusion. The expression of liver IEGs was not induced by warm ischemia and cold preservation alone. Reperfusion of livers following warm ischemia or cold preservation resulted in a distinctly different pattern of gene expression in viable and nonviable livers. In shunted LI and fresh liver OLT groups (viable), c-fos and c-jun mRNAs increased markedly to a peak value within 1-2 hr of reperfusion, returning to basal level by 3 hr. In nonviable livers, the level of these mRNAs was ...Continue Reading

Citations

Dec 20, 2000·Transplantation Proceedings·T TsuchiyaM Gotoh
Mar 27, 2001·Transplantation Proceedings·T L PanC L Chen
Dec 5, 1998·Transplantation Proceedings·T L PanC L Chen
Oct 26, 1999·Transplantation·H N SankaryJ W Williams
Apr 16, 2008·Journal of Gastroenterology and Hepatology·Yock Young Dan, George C Yeoh
Jul 1, 2008·Regenerative Medicine·Jörg C GerlachJohn F Patzer Ii
Oct 28, 2004·Experimental and Molecular Pathology·Yukiko MiyatakeTakashi Yoshiki
Feb 9, 2002·The Annals of Thoracic Surgery·David P NelsonEllis J Neufeld
Mar 27, 2001·The Journal of Surgical Research·F DeboneraK M Olthoff
Jan 8, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyohito YagiHajime Ohgushi

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