PMID: 2114536Jun 1, 1990Paper

The induction of micronucleated polychromatic erythrocytes in mice using single and multiple treatments

Mutation Research
R R TiceM D Shelby

Abstract

Studies are reviewed in which the effect of treatment/sample protocol on the induction of micronucleated polychromatic erythrocytes (MN-PCE) in male B6C3F1 mice by 3 carcinogens (benzidine, dimethylbenzanthracene and mitomycin C) were evaluated. 3 different treatment/sampling protocols were used, involving from 1 to 3 consecutive daily treatments and from 3 to 1, respectively, consecutive daily samplings beginning 24 h after the last injection. The results indicate that the 3-day injection/single sample time protocol eliminates the need for multiple sample times, minimizes the number of animals required in a study, decreases the time needed for data collection and simplifies data analysis. A comparison of the frequency of induced MN-PCE in peripheral blood and bone marrow suggests that, following a 3-injection protocol, either tissue can be used with equal efficiency.

Citations

Jun 1, 1994·Mutation Research·M HayashiH Shimada
Jan 1, 1992·Mutation Research·A F McFeeM D Shelby
Mar 25, 1996·Molecular and Cellular Endocrinology·E SewerynekW M Daniels
Jul 4, 1998·Toxicology Letters·D MelchiorriG Nisticò
Apr 1, 1993·Environmental Health Perspectives·R W Tennant, E Zeiger
May 12, 2000·Environmental Health Perspectives·M M Moore, K Harrington-Brock
Nov 16, 2004·Annals of the New York Academy of Sciences·S Balachandra Dass, Syed F Ali
Jan 29, 2003·Environmental and Molecular Mutagenesis·Genaro G OrtizOscar K Bitzer-Quintero
Aug 14, 2020·Journal of Toxicology and Environmental Health. Part a·Daniel Luís Viana CruzMíriam Silva Rafael
Jan 1, 1993·Environmental and Molecular Mutagenesis·M D ShelbyR R Tice
Feb 17, 2021·International Journal of Radiation Biology·Kanokporn Noy RithidechLouise Honikel

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