The induction of the lupus phenotype by estrogen is via an estrogen receptor-alpha-dependent pathway

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Feng FengJerrie Gavalchin

Abstract

In order to investigate the roles of ER subtypes in the estrogen-induced lupus phenotype, ERalpha-deficient (ERalpha(-/-)) and wild-type mice (WT) were injected monthly with estradiol (E-2) starting at 8 weeks. In WT mice, E-2 treatment induced a lupus phenotype, with accelerated death and increased kidney damage, as well as Th2-type serum cytokine and autoantibody production. In contrast, only minimal changes were observed in ERalpha(-/-) mice after E-2 treatment. In a separate study, we found that in immune cells of autoimmune-prone SNF(1) and non-autoimmune DBF(1) mice, both ERalpha and ERbeta were differentially expressed and modulated by E-2. In SNF(1) mice, there were more CD4(+) and CD8(+) T cells constitutively expressing ERalpha, and the percentages of ERalpha+ dendritic cells and macrophages were increased after E-2 exposure compared to DBF(1) mice. Taken together, these observations strongly suggest a role for ERalpha in E-2-induced development of the lupus phenotype.

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Citations

Jul 27, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tomasz MajAnna Che Mo Ska-Soyta
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Maria Gulinello, Chaim Putterman
Apr 22, 2016·Histochemistry and Cell Biology·Osamu IchiiYasuhiro Kon
Jan 1, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nicholas A YoungWael N Jarjour
Jun 17, 2010·The Journal of Rheumatology·Yu ZhangElena Peeva
Oct 20, 2018·Frontiers in Immunology·Vaishali R Moulton
Mar 20, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa A Brown, Maureen A Su
Apr 13, 2018·Frontiers in Immunology·Virginia RiderBrooke L Fridley
Apr 1, 2021·Renal Failure·Hao-Yang MaYang Du

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