The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures

Cancer Letters
G S Probst, S B Neal

Abstract

The autoradiographic identification of chemically-induced, unscheduled DNA synthesis in primary cultures of adult rat hepatocytes is currently being validated as a predictive test for mutagens/carcinogens. Of 8 antihistaminic drugs tested, 2, pyrilamine maleate and tripelennamine HCl, were positive for unscheduled DNA synthesis. Further investigation of the mutagenic/carcinogenic potential of these compounds in alternate test systems is suggested.

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Citations

Feb 18, 2011·Archives of Toxicology·Giovanni BrambillaAntonietta Martelli
Aug 1, 1992·Mutation Research·G Brambilla, A Martelli
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Jan 1, 1983·Environmental Mutagenesis·C A McQueenG M Williams

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