The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ankur Rohilla, Pitchai Balakumar

Abstract

Recently we have demonstrated that the cardioprotective potential of ischemic postconditioning (IPOC) against ischemia and reperfusion (I/R)-induced myocardial injury was markedly suppressed in hyperhomocysteinemic (Hhcy) rat hearts. The present study investigated the possible role of PKC-delta in Hhcy-induced suppression of myocardial infarct size-limiting effect of IPOC. Isolated Langendorff's perfused normal and Hhcy rat hearts were subjected to 30-min global ischemia (I), followed by 120-min reperfusion (R). The myocardial damage was assessed by measuring the infarct size, and analyzing the release of LDH and CK-MB in coronary effluent. The oxidative stress in the heart was assessed by measuring lipid peroxidation and superoxide anion generation. The I/R produced myocardial injury in normal and Hhcy rat hearts by increasing myocardial infarct size, LDH and CK in coronary effluent and oxidative stress. Hhcy rat hearts exhibited enhanced I/R-induced myocardial injury and high oxidative stress as compared to normal rat hearts subjected to I/R. The IPOC (six brief episodes of I/R, 10s each) afforded cardioprotection against I/R-induced myocardial injury in normal rat hearts; but IPOC-mediated cardioprotection was abolished in H...Continue Reading

References

Aug 6, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·V Parikh, M Singh
May 19, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A Sharma, M Singh
Mar 15, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Sulochana DeviJacob Joseph
May 12, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarMadhu B Anand-Srivastava
May 21, 2009·Methods and Findings in Experimental and Clinical Pharmacology·Pitchai BalakumarManjeet Singh

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Citations

Oct 7, 2011·Archives of Pharmacal Research·Ankur RohillaAshok Kushnoor
Oct 12, 2012·Journal of Advanced Pharmaceutical Technology & Research·Ankur RohillaRazia Khanam
Jan 30, 2014·Scandinavian Cardiovascular Journal : SCJ·Jun FangLingzhen Wu
Jun 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Li ChenMing Guo

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