The Infection Process of Yersinia ruckeri : Reviewing the Pieces of the Jigsaw Puzzle

Frontiers in Cellular and Infection Microbiology
José A GuijarroJessica Méndez

Abstract

Finding the keys to understanding the infectious process of Yersinia ruckeri was not a priority for many years due to the prompt development of an effective biotype 1 vaccine which was used mainly in Europe and USA. However, the gradual emergence of outbreaks in vaccinated fish, which have been reported since 2003, has awakened interest in the mechanism of virulence in this pathogen. Thus, during the last two decades, a large number of studies have considerably enriched our knowledge of many aspects of the pathogen and its interaction with the host. By means of both conventional and a variety of novel strategies, such as cell GFP tagging, bioluminescence imaging and optical projection tomography, it has been possible to determine three putative Y. ruckeri infection routes, the main point of entry for the bacterium being the gill lamellae. Moreover, a wide range of potential virulence factors have been highlighted by specific gene mutagenesis strategies or genome-wide transposon/plasmid insertion-based screening approaches, such us in vivo expression technology (IVET) and signature tagged mutagenesis (STM). Finally, recent proteomic and whole genomic analyses have allowed many of the genes and systems that are potentially implic...Continue Reading

References

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Jul 6, 2014·Diseases of Aquatic Organisms·Ségolène CalvezPatrick Daniel

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Citations

Sep 14, 2019·Genes·Agnieszka WrobelDirk Linke
Mar 22, 2020·Veterinary Research·Simon Menanteau-LedoubleMansour El-Matbouli
Sep 24, 2021·Environmental Science and Pollution Research International·Elham Alsadat BanihashemiMahdi Banaee

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Methods Mentioned

BETA
flow cytometry
GTPase
RNA-seq

Software Mentioned

OPT
IVET

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