PMID: 7520206Jan 1, 1994Paper

The inflammatory lesion of T cell line transferred experimental autoimmune encephalomyelitis of the Lewis rat: distinct nature of parenchymal and perivascular infiltrates

Acta Neuropathologica
J Lannes-VieiraH Wekerle

Abstract

We have investigated the T cell receptor (TCR) repertoire in the inflammatory infiltrates of T line-transferred experimental autoimmune encephalomyelitis (EAE) of the Lewis rats. Using a panel of TCR V beta-specific monoclonal antibodies (mAbs) and immunocytochemistry, we studied the nature of the T cells entering the central nervous system (CNS) after transfer of either myelin basic protein (MBP)-reactive, or MBP-reactive but non-encephalitogenic T cell lines. All the MBP-specific T cell lines predominantly used the V beta 8.2 TCR chain. T cell lines specific for the tuberculin purified protein derivative (PPD), using TCR V genes different from V beta 8.2, served as controls. We first studied the time course of T cells entering the CNS. In all recipient rats, small, but significant numbers of alpha beta-TCR-expressing infiltrate cells appeared in the CNS within the first 24 h after T cell transfer. In animals injected with either type of MBP-reactive T cells, the early infiltrate cells were preferentially located within the parenchyma of the spinal cord, while in PDD T line-injected rats, the lymphocytes were mostly found in the meninges. TCR V beta gene usage was examined on the peak of clinical disease. Six days after T cell...Continue Reading

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Citations

Jan 1, 1996·Springer Seminars in Immunopathology·M Bradl
Sep 1, 1995·Journal of Neuroimmunology·B KalmanF D Lublin
Dec 1, 1995·Current Opinion in Immunology·J BauerH Lassmann
Aug 12, 2003·Brain Research Bulletin·F Sellebjerg, T L Sørensen
Jan 29, 1999·Research in Immunology·T OwensM Krakowski
Mar 7, 2002·Journal of Neuroimmunology·Fei SongCaroline C Whitacre
Feb 11, 2015·Immunobiology·Jana BlaževskiDjordje Miljković
Apr 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·H D Webster
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard E JonesDennis Bourdette

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