The inflammatory response to miniaturised extracorporeal circulation: a review of the literature.

Mediators of Inflammation
Hunaid A VohraSunil K Ohri

Abstract

Conventional cardiopulmonary bypass can trigger a systemic inflammatory response syndrome similar to sepsis. Aetiological factors include surgical trauma, reperfusion injury, and, most importantly, contact of the blood with the synthetic surfaces of the heart-lung machine. Recently, a new cardiopulmonary bypass system, mini-extracorporeal circulation (MECC), has been developed and has shown promising early results in terms of reducing this inflammatory response. It has no venous reservoir, a reduced priming volume, and less blood-synthetic interface. This review focuses on the inflammatory and clinical outcomes of using MECC and compares these to conventional cardio-pulmonary bypass (CCPB). MECC has been shown to reduce postoperative cytokines levels and other markers of inflammation. In addition, MECC reduces organ damage, postoperative complications and the need for blood transfusion. MECC is a safe and viable perfusion option and in certain circumstances it is superior to CCPB.

Associated Clinical Trials

References

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Citations

Nov 26, 2010·Artificial Organs·Heike SchnoeringJaime F Vazquez-Jimenez
Mar 19, 2014·Journal of cardiology·Nikolaos G BaikoussisEfstratios Apostolakis
Feb 28, 2015·Oxidative Medicine and Cellular Longevity·Mustafa ZakkarGianni D Angelini
Nov 18, 2015·Oxidative Medicine and Cellular Longevity·Emad Al JaalyGianni D Angelini
Mar 23, 2011·Annual Review of Biomedical Engineering·Stephen F BadylakKorkut Uygun
Jan 1, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Manabu TakanashiMasahiro Ishii
Sep 12, 2015·Perfusion·Y M GanushchakP W Weerwind
Apr 18, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·György LangWalter Klepetko
Jun 22, 2012·Asian Cardiovascular & Thoracic Annals·Chanaka RajakarunaClinton Lloyd
Feb 18, 2012·Perfusion·Y M GanushchakP W Weerwind
Jan 1, 2017·Oxidative Medicine and Cellular Longevity·Ayse Dogan, Fevzi Sarper Turker
Jun 17, 2014·Journal of Cardiovascular Medicine·Gianluigi BisleriClaudio Muneretto
Jan 26, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yutaka FujiiEisuke Tatsumi
Jun 18, 2021·Prague Medical Report·Michal PořízkaBasem B Abdelmalak

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Methods Mentioned

BETA
coronary artery bypass
MDA

Software Mentioned

MECC

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