The inflammatory response to ruptured abdominal aortic aneurysm is altered by endovascular repair

International Journal of Vascular Medicine
Ragai Reda MakarBernard Lee

Abstract

Introduction. Ruptured abdominal aortic aneurysm (rAAA) causes a significant inflammatory response. The study aims to investigate this response following endovascular and open repair of ruptured AAA. Patients and Methods. Consecutive rAAA patients had either endovascular aneurysm repair (EVAR) or open repair (OR). Blood samples were taken for cytokines, lipid hydroperoxides (LOOH), antioxidants, and neutrophil elastase/ α 1-anti-trypsin complexes (NE/AAT) before surgery, 6 hours after clamp release and 1, 3, 5 days postoperatively. Results. 30 patients were included in the study, with 14 undergoing eEVAR and 16 eOR, with comparable baseline comorbidities, age, and parameters. IL-6 peaked higher in eOR patients (P = 0.04), while p75TNFr was similar between groups except at day 5 (P = 0.04). The NE/AAT concentrations were higher in eOR patients (P = 0.01), particularly in the first postoperative day, and correlated with blood (r = 0.398, P = 0.029) and platelet (r = 0.424, P = 0.020) volume transfused. C-reactive protein rose and lipid hydroperoxide fell in both groups without significant intergroup difference. Vitamins C and E, lycopene, and β -carotene levels were similar between groups. Conclusion. EVAR is associated with lowe...Continue Reading

References

Jan 1, 1991·The American Journal of Clinical Nutrition·T YoshikawaM Kondo
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Sep 1, 1980·The Journal of Clinical Investigation·P J SpagnuoloM J Dunn
Dec 1, 1995·The American Journal of Clinical Nutrition·H Sies, W Stahl
May 1, 1993·The American Journal of Clinical Nutrition·B Halliwell, S Chirico
Jul 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M M ThompsonP R Bell
Mar 1, 1997·American Journal of Surgery·G P NovelliS Capaccioli
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
Jun 20, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·I SykB Risberg
Jul 3, 1998·Biochemical Society Transactions·A BrownD Mantle
Apr 8, 1999·Intensive Care Medicine·P G MetnitzW Druml
May 22, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L L LauC V Soong
Oct 2, 2001·The British Journal of Surgery·T E Rowlands, S Homer-Vanniasinkam
Nov 16, 2004·Biochimica Et Biophysica Acta·Sandro ArgüellesAntonio Ayala
Aug 19, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seitaro FujishimaNaoki Aikawa

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Citations

May 6, 2017·BioMed Research International·Magdalena BudzyńMaria Iskra

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Methods Mentioned

BETA
enzyme-linked immunoassay

Software Mentioned

eEVAR
SPSS

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