The Inflammatory Role of Platelets via Their TLRs and Siglec Receptors

Frontiers in Immunology
Fabrice CognasseOlivier Garraud

Abstract

Platelets are non-nucleated cells that play central roles in the processes of hemostasis, innate immunity, and inflammation; however, several reports show that these distinct functions are more closely linked than initially thought. Platelets express numerous receptors and contain hundreds of secretory products. These receptors and secretory products are instrumental to the platelet functional responses. The capacity of platelets to secrete copious amounts of cytokines, chemokines, and related molecules appears intimately related to the role of the platelet in inflammation. Platelets exhibit non-self-infectious danger detection molecules on their surfaces, including those belonging to the "toll-like receptor" family, as well as pathogen sensors of other natures (Ig- or complement receptors, etc.). These receptors permit platelets to both bind infectious agents and deliver differential signals leading to the secretion of cytokines/chemokines, under the control of specific intracellular regulatory pathways. In contrast, dysfunctional receptors or dysregulation of the intracellular pathway may increase the susceptibility to pathological inflammation. Physiological vs. pathological inflammation is tightly controlled by the sensors ...Continue Reading

Citations

Feb 6, 2016·Future Microbiology·Olivier GarraudBruno Pozzetto
Nov 10, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lacey JohnsonDenese C Marks
Aug 22, 2015·Thrombosis and Haemostasis·Mark R Thomas, Robert F Storey
Jan 21, 2016·Journal of Thrombosis and Haemostasis : JTH·Fabrice CognasseHind Hamzeh-Cognasse
Jun 20, 2015·Frontiers in Immunology·Olivier Garraud
Jun 9, 2015·The Journal of Allergy and Clinical Immunology·Marco IdzkoClive Page
May 18, 2016·Experimental Biology and Medicine·Seema Nandi, Ashley C Brown
Oct 4, 2016·Transfusion·Jennifer A MuszynskiUNKNOWN Pediatric Critical Care Blood Research Network (Blood Net)
Oct 19, 2016·International Journal of Molecular Sciences·Susann PankratzKerstin Göbel
Feb 22, 2017·Frontiers in Immunology·Pauline DamienHind Hamzeh-Cognasse
Mar 24, 2017·The Journal of Trauma and Acute Care Surgery·Sanjna ShahJennifer A Muszynski
Feb 1, 2018·Transfusion·Kenneth E RemyUNKNOWN Pediatric Critical Care Blood Research Network (Blood Net)
Mar 22, 2018·Nature Reviews. Rheumatology·Petrus LingeEric Boilard
Dec 29, 2017·Medicinal Research Reviews·Mojtaba Khajeh Alizadeh AttarNima Rezaei
Jun 20, 2018·Infection and Immunity·Sharmeen NishatRandall G Worth
Jan 20, 2018·Circulation Research·Milka KoupenovaJane E Freedman
Sep 11, 2018·CPT: Pharmacometrics & Systems Pharmacology·Anisur RahmanTimothy Hickling
Nov 6, 2018·Expert Review of Clinical Immunology·Giacomo CafaroRoberto Gerli
Jan 19, 2019·PloS One·Brigette ChurchCaroline E Cameron
Mar 2, 2018·Rheumatology International·Zuzanna Małgorzata ŁukasikJoanna Samanta Makowska
Oct 9, 2015·Current Opinion in Oncology·Antonio MoscardóJuana Vallés
Sep 17, 2019·Platelets·Krishna S Iyer, Sanjana Dayal
Sep 16, 2018·Blood Advances·Ruqayyah J AlmizraqJennifer A Muszynski
Feb 13, 2020·Clinical and Experimental Immunology·L Frasca, R Lande
Jul 31, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Alaa Efat HassanMohamed Abdelhafez
Aug 26, 2020·Blood Advances·Waltraud C SchrottmaierMattias N E Forsell
Dec 15, 2016·Frontiers in Immunology·Olivier GarraudF Cognasse
Jul 20, 2017·The Journal of Experimental Medicine·Jackson LiangYao LiAndrés Hidalgo
Jul 25, 2018·Infection and Immunity·Vesla KullayaAndre J van der Ven
Sep 12, 2018·Scientific Reports·Fanny Vardon BounesBernard Payrastre
Apr 11, 2019·International Journal of Molecular Sciences·Cristina Gomez-CasadoMaria M Escribese
Jul 2, 2019·Experimental and Therapeutic Medicine·Xinlei ChenXiangyan Liu
Sep 26, 2019·Current Pharmaceutical Design·Vivek K YadavSunil K Singh
Jul 22, 2017·Cancer Metastasis Reviews·David G MenterKenneth V Honn

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
O Garraud, F Cognasse
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
F CognasseO Garraud
Biomedical Journal
Najwane Saïd-Sadier, David M Ojcius
Gastroenterology Research and Practice
John EvankovichAllan Tsung
© 2021 Meta ULC. All rights reserved