The influence of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on dental root resorption in the mouse

Calcified Tissue International
P R Wesselink, W Beertsen

Abstract

It has been hypothesized that phagocytosis of a layer of mineralized material which is sometimes deposited along the root surface following trauma is an important factor in the initiation of the resorption of teeth. To test this hypothesis, freezing of the mouse incisor periodontium was used as a model where deposition of mineral was prevented by the systemic administration of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP, 10 mg P/kg b.w.) for time periods varying from 2 to 31 days. The animals were killed either 24 hours or 1 month after the last injection and their mandibles were processed for light microscopy. In the HEBP-treated animals, killed 24 hours after the last injection, no mineralized material had been deposited along the root surface, and very little resorption was seen. Large amounts of bone matrix were deposited in the intraperiodontal space (often causing localized ankylosis). In HEBP-treated animals killed 1 month after the last injection, again no layer of mineralized material along the root surface was seen, but now root resorption had become manifest, occupying up to 40% of the cement surface. This occurred irrespective of the duration of HEBP administration. In the saline-treated animals, extensive resorpti...Continue Reading

Citations

Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S M Ott
Aug 1, 1994·Journal of Clinical Periodontology·P R Wesselink, W Beertsen
Aug 1, 1994·Journal of Clinical Periodontology·P R Wesselink, W Beertsen
Nov 9, 2005·Journal of Periodontology·Yong-Hee P ChunMartha J Somerman
Feb 1, 1996·Acta Odontologica Scandinavica·I Alatli, L Hammarström
Feb 1, 1995·Endodontics & Dental Traumatology·F R LiewehrD H Pashley
May 13, 2008·European Journal of Oral Sciences·Agnès Kamoun-GoldratMartine Le Merrer
Jun 27, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F VaysseS Cousty
Jun 21, 2014·Clinical Oral Investigations·Paulo de Camargo MoraesVera Cavalcanti de Araújo
May 21, 2019·American Journal of Botany·Cody Coyotee HowardNico Cellinese

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