PMID: 8583367Aug 1, 1995Paper

The influence of 17-beta-oestradiol and the natural oestrous cycle on alpha-adrenoceptor-mediated responses of the cardiovascular system in the rat

The Journal of Pharmacy and Pharmacology
C Austin, R Chess-Williams

Abstract

The effect of 17 beta-oestradiol pretreatment and the natural oestrous cycle on responses of rat cardiac and vascular alpha-adrenoceptors was investigated. It was found that treatment with the oestrogen had no effect on cardiac adrenoceptor sensitivity, while pretreatment with the hormone caused a significant increase in vascular alpha 2-, but not vascular alpha 1-adrenoceptor responsiveness. Pressor responses of pithed rats to selective alpha 1- or alpha 2-adrenoceptor agonists did not alter, however, during the natural oestrous cycle. These findings suggest that changes in oestrogen levels are capable of altering alpha-adrenoceptor-mediated vascular responses but that the relatively small changes in oestrogen which may occur throughout the natural oestrous cycle do not appear to alter the responses of these vascular alpha-adrenoceptors.

References

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Citations

Jun 6, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hajime WatanabeTaisen Iguchi
Nov 8, 2002·Pharmacology & Toxicology·Ole Saetrum OpgaardDiana N Krause

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