Abstract
Groups of guinea pigs sensitized with ovalbumin were treated with budesonide and beclomethasone dipropionate, respectively, in an intraperitoneal dose of 50 mg/kg. 20 h later, the anaphylactic release of histamine and slow reacting substance of anaphylaxis (SRS-A) from chopped lung tissue was studied. Whereas the corticosteroids studied had no effect on the tissue content of histamine or on the amount of antigen-induced release of this autacoid, budesonide and beclomethasone dipropionate to a great extent inhibited the release of SRS-A. The anti-anaphylactic effect of budesonide and beclomethasone was also shown in sensitized guinea pigs pretreated with mepyramine, 2.5 mg/kg intraperitoneally, and challenged with nebulized ovalbumin. We suggest that the partial protection given by the corticosteroids budesonide and beclomethasone dipropionate is due to the inhibiton of SRS-A release.
References
Jul 1, 1977·Prostaglandins·M K BachR R Gorman
Jan 1, 1975·International Archives of Allergy and Applied Immunology·W Schmutzler, G P Freundt
Jan 1, 1975·Drugs·R N BrogdenG S Avery
May 1, 1975·Acta Physiologica Scandinavica·K Strandberg, P Hedqvist
Jan 1, 1979·British Journal of Pharmacology·J F Burka, R J Flower
Jan 1, 1979·International Archives of Allergy and Applied Immunology·K Forsberg, L Sörenby
Mar 29, 1979·Nature·R J Flower, G J Blackwell
Nov 1, 1975·British Journal of Pharmacology·M K Church
Jan 1, 1971·International Archives of Allergy and Applied Immunology·R P Orange, K F Austen
Nov 1, 1974·The Journal of Experimental Medicine·R A LewisK F Austen
Mar 1, 1969·The Journal of Pharmacy and Pharmacology·R Hicks
Mar 1, 1970·The Journal of Pharmacy and Pharmacology·R Hicks
Sep 1, 1972·British Journal of Pharmacology·M K ChurchG W James
Dec 1, 1971·Acta Allergologica·O A Olsson
Feb 1, 1980·Journal of Pharmaceutical Sciences·R D Krell, L W Chakrin
Jun 1, 1960·The Journal of Physiology·W E BROCKLEHURST
Feb 1, 1964·The Journal of Pharmacy and Pharmacology·P GOADBY, W G SMITH
Citations
Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Mar 1, 1986·Prostaglandins·W M AbrahamL D Yerger
Mar 1, 1986·Prostaglandins·W M AbrahamG A Chapman
Mar 1, 1993·British Journal of Pharmacology·M HashimotoM Katori
Aug 1, 1984·British Journal of Pharmacology·R D Krell, E J Kusner
May 1, 1982·British Journal of Pharmacology·P Andersson, R Brattsand
Oct 1, 1982·British Journal of Pharmacology·P Andersson
Dec 1, 1989·Biochemical Pharmacology·E J KusnerR D Krell
Nov 1, 1989·Agents and Actions·W KreutnerC Rizzo