The influence of a restrictive atrial septal defect on pulmonary vascular morphology in patients with hypoplastic left heart syndrome

Pediatric Cardiology
Joseph N GrazianoA Ludomirsky


Hypoplastic left heart syndrome (HLHS) with a restrictive atrial septal defect (ASD) is a form of congenital heart disease with considerable morbidity and mortality. This morphologic analysis assesses the pulmonary vasculature in this patient population. Pulmonary arteries, the persistence of high-resistance fetal arterioles, pulmonary veins, and lymphatics from multiple lung sections from each of five patients with HLHS and a restrictive ASD were compared to those of five patients with HLHS and nonrestrictive ASD. Lung sections from each patient were qualitatively graded in severity of pathology from 0 to 3 for each of the structures described previously, with the pathologist blinded to the status of the ASD. Patients with a restrictive ASD exhibited more significant pulmonary venous thickening and lymphatic dilatation (p = 0.02), with a tendency toward persistence of high-resistance fetal vessels (p = 0.2), compared to patients with a nonrestrictive ASD. These findings imply that patients with HLHS and a restrictive ASD possess pulmonary vascular abnormalities that place them at higher risk for the current surgical interventions available compared to patients with a nonrestrictive ASD.


Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael WeidenbachIngo Daehnert
Feb 5, 2004·The Annals of Thoracic Surgery·Paul A ChecchiaLeonard L Bailey
Mar 6, 2004·Seminars in Neonatology : SN·Caren S Goldberg, Carlen A Gomez
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Therese M Giglia, Tilman Humpl
Dec 31, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sanjeev A DatarJeffrey R Fineman
Jan 2, 2010·Circulation. Cardiovascular Imaging·Anita SzwastJack Rychik
Aug 28, 2014·Cardiology in the Young·Ulrike HerbergJohannes Breuer
Jun 28, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Brian T KalishAudrey C Marshall
Oct 5, 2010·The Journal of Thoracic and Cardiovascular Surgery·Jodie Y DuffyPirooz Eghtesady
Oct 24, 2007·The Annals of Thoracic Surgery·Jenifer A GlatzJack Rychik
Dec 6, 2005·Clinics in Perinatology·Anita Szwast, Jack Rychik
Aug 3, 2013·General Thoracic and Cardiovascular Surgery·Shoji SuzukiMasahiko Matsumoto
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Fionnuala M McAuliffeJo-Ann Johnson
Mar 14, 2017·Cardiology in the Young·Jeremy L HerrmannJennifer E Pogoriler
Mar 12, 2013·Seminars in Cardiothoracic and Vascular Anesthesia·Brian M Fonseca
Apr 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Catherine J MorrisSanjeev A Datar
Feb 26, 2015·Circulation. Cardiovascular Interventions·Andrew EdwardsFlora Y Wong
Apr 26, 2014·Circulation·Mary T DonofrioUNKNOWN American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in
Jun 24, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F Lenz, R Chaoui
Oct 20, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Yosuke FukushimaShinichi Otsuki
Aug 13, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexander J JavoisTarek S Husayni
Sep 1, 2005·Pediatric Cardiology·J N Graziano
Mar 21, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jeffrey G GossettJoseph N Graziano
Sep 9, 2015·Cardiology in the Young·Shyam K SathanandamBettina F Cuneo
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Sanjeev A DatarJeffrey R Fineman
Aug 25, 2016·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Romi NangaluHarmesh Singh Bains
Jul 11, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Ray S ChoiMorgan L Brown
Jul 7, 2017·Pulmonary Circulation·Thomas J Kulik, Eric D Austin
Jan 29, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Annak JadczakUNKNOWN International Prenatal Cardiology Collaboration Group
Dec 1, 2020·Pediatric Radiology·Christian A BarreraDavid M Biko
Apr 16, 2021·Pediatric Radiology·Christian A BarreraTeresa Victoria

❮ Previous
Next ❯

Related Concepts

Related Feeds


Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.