PMID: 44915Jan 1, 1979

The influence of acetate versus bicarbonate on patient symptomatology during dialysis

Proceedings of the European Dialysis and Transplant Association
K NagaiB H Scribner


The effect of large-surface area dialysis (LS) using dialysate containing both acetate and bicarbonate (LS-C) on a patient's symptomatology was compared with that noted with acetate (LS-A) or bicarbonate (LS-B) in the dialysis fluid. Patients experienced significantly more symptoms and deterioration of objective performance test scores with both LS-A and LS-C than LS-B. Furthermore, a correlation was seen between plasma acetate level at the end of dialysis and decrement in the performance test scores. The results suggest that accumulation of acetate rather than acute alteration in acid-base status is primarily responsible for the morbidity.

Related Concepts

Acetic Acids
Carbonic Acid Ions
Carbon Dioxide
Physical Dialysis
Vertex Headache
Hydrogen-Ion Concentration

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