The influence of actin microfilaments on signaling by the receptor with high-affinity for IgE

Molecular Immunology
Chikako TorigoeHenry Metzger

Abstract

Aggregation of the receptors with high-affinity for IgE (FcRI) stimulates a variety of cellular responses, but excessive aggregation inhibits such responses. Actin filaments have been implicated in the inhibitory phenomenon because disrupting the filaments enhances the cellular reactions stimulated by the aggregated receptors. To clarify further the molecular mechanism and physiological importance of the actin-mediated inhibition, we assessed the effect of inhibitors of actin polymerization on the initial signaling events of mast cells alternatively stimulated by nitrophenyl ligands that dissociate slowly (high-affinity) or rapidly (low-affinity) from receptor-bound anti-dinitrophenyl IgE. The inhibitors amplified the phosphorylation of FcRI and of Syk induced by addition of either ligand but at physiological temperatures, the augmentation of the response to the low-affinity ligand was especially exaggerated. The effect of actin is on the earliest events, and although the molecular mechanism(s) by which the filaments regulate the intensity of proximal signaling remains unclear, several possibilities have been excluded. That the inhibitors only minimally augment the responses stimulated by preformed dimers of IgE, and in general...Continue Reading

Citations

Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alexis J TorresBarbara A Baird
Jun 9, 2009·Journal of Structural Biology·Michael L Dustin
Jan 15, 2013·Journal of Ethnopharmacology·Ju Dong KimWahn Soo Choi
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chikako TorigoeByron Goldstein
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Gaël MénaschéUlrich Blank

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