The influence of acute pulmonary hypertension on cardiac output measurements: calibrated pulse contour analysis, transpulmonary and pulmonary artery thermodilution against a modified Fick method in an animal model.

Anesthesia and Analgesia
Annette P N KutterC K Hofer

Abstract

In critically ill patients with significant pulmonary hypertension (PH), close perioperative cardiovascular monitoring is mandatory, considering the increased morbidity and mortality in this patient group. Although the pulmonary artery catheter is still the standard for the diagnosis of PH, its use to monitor cardiac output (CO) in patients with PH is decreasing as a result of increased morbidity and possible influence of tricuspid regurgitation on the measurements. However, continuous CO measurement methods have never been evaluated under PH regarding their agreement and trending ability. In this study, we evaluated the influence of acute PH and different CO states on transpulmonary thermodilution (TPTD) and calibrated pulse contour analysis (PiCCO; both assessed with PiCCO plus™), intermittent pulmonary artery thermodilution (PATD), and continuous thermodilution (CCO) compared with a modified Fick method (FICK) in an animal model. Nine healthy pigs were studied under anesthesia. PH of 25 and 40 mm Hg (by administration of the thromboxane analog U46619), CO decreases, and CO increases were induced to test the different CO measurement techniques over a broad range of hemodynamic situations. Before each step, a new baseline data...Continue Reading

References

Feb 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T Nishikawa, S Dohi
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·M M HoeperH Fabel
Apr 20, 2001·Journal of Cardiothoracic and Vascular Anesthesia·P M HeerdtC W Hogue
Nov 27, 2002·The European Respiratory Journal·D ChemlaS Brimioulle
Feb 13, 2003·Journal of Clinical Monitoring and Computing·L A Critchley, J A Critchley
Apr 24, 2004·Intensive Care Medicine·Alain CombesJean-Louis Trouillet
Dec 19, 2006·Journal of the American College of Cardiology·Marius M HoeperLewis J Rubin
Jun 20, 2007·British Journal of Anaesthesia·H-C LaiT-J Liu
Apr 11, 2008·Critical Care Medicine·Mark D PiehlBruce A Cairns
Aug 26, 2010·Anesthesia and Analgesia·Lester A CritchleyAnthony M-H Ho
Nov 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Mehrnaz HadianMichael R Pinsky
Mar 23, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Lester A CritchleyAnna Lee
Jun 26, 2012·Veterinary Anaesthesia and Analgesia·Rima N BektasRegula Bettschart-Wolfensberger
Jul 11, 2013·British Journal of Anaesthesia·S M Axiak FlammerS Vandenberghe
Dec 21, 2013·Journal of the American College of Cardiology·Marius M HoeperDavid B Badesch
Mar 1, 2014·Veterinary Anaesthesia and Analgesia·Sonja Hartnack

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