The influence of adhesive and invasive properties of Staphylococcus aureus defective in fibronectin-binding proteins on secretion of interleukin-6 by human endothelial cells

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Bo SöderquistErik Kihlström

Abstract

Fibronectin-binding proteins (FnBP) are surface adhesins of Staphylococcus aureus documented to be virulence attributes in, for example, endovascular infections. By using mutants of S. aureus defective in the FnBPA and B genes we have investigated whether these adhesins affect cytokine expression in human umbilical vein endothelial cells (HUVEC). S. aureus expressing FnBPA and B adhered to and were internalized into HUVEC to a greater extent compared to mutants defective in expression of FnBP. Production and release of IL-6 was higher from endothelial cells infected with the parent FnBP-expressing strain compared to the FnBP-defective mutants. These results indicate that adhesion to and invasion of S. aureus into endothelial cells are important regulators of cytokine expression.

References

Dec 1, 1990·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·R A Proctor
Jul 1, 1987·Reviews of Infectious Diseases·R J Hamill
May 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J KällmanE Kihlström
Feb 26, 1999·Trends in Microbiology·T J Foster, M Höök
Mar 3, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B SöderquistE Kihlström

❮ Previous
Next ❯

Citations

Jun 27, 2012·The Journal of Infectious Diseases·Suman Laal
Aug 11, 2010·FEMS Microbiology Reviews·Brian HendersonMark A Williams
Nov 11, 2006·FEMS Immunology and Medical Microbiology·Wan Beom ParkKang Won Choe
Jun 18, 2015·PloS One·Inés OmraneAmel Benammar-Elgaaied

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.