PMID: 7085302May 1, 1982Paper

The influence of aerosol size on retention and translocation of 241Am following inhalation of 241AmO2 by beagles

Health Physics
J A MewhinneyB A Muggenburg

Abstract

Beagle dogs received a single inhalation exposure to a monodisperse or a polydisperse aerosol of 241AmO2 to determine the radiation dose to internal organs. Three monodisperse aerosol sizes (0.75, 1.5 and 3.0 micrometer activity median aerodynamic diameter) and one polydisperse aerosol (1.8 micrometer activity median aerodynamic diameter) were used to assess the role of particle size in clearance of 241AmO2 from the lung and the rate of translocation of 241Am to other tissues. Dogs were sacrificed in groups of two or three at 8, 32, 64, 128, 256, 365 and 730 days after exposure. The clearance rate of 241Am from lung was particle size dependent; this resulted in an increased radiation dose to lung at 2 yr by 70% as particle size increased from 0.75 to 3.0 micrometer aerodynamic diameter. Conversely, the radiation dose to liver and skeleton decreased by 20 and 35% respectively as particle size increased from 0.75 to 3.0 micrometer activity median aerodynamic diameter. When the radiation doses absorbed by lung, liver and skeleton were compared to those predicted by the ICRP 30 model, differences were noted.

Citations

Nov 3, 2007·Radiation Protection Dosimetry·Vera Becková, Irena Malátová
May 1, 1990·American Journal of Respiratory Cell and Molecular Biology·W G KreylingJ D Brain
Jul 1, 1992·Environmental Health Perspectives·W G Kreyling
Feb 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R A Guilmette, B A Muggenburg
Jul 1, 1992·International Journal of Radiation Biology·A Taya, J A Mewhinney
Dec 19, 2019·Annals of the ICRP·F PaquetJ D Harrison
Jun 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R A GuilmetteR O McClellan

Related Concepts

Americium oxide, 241AM-labeled
Aerosol Dose Form
Americium
Canis familiaris
Respiration
Drug or Chemical Tissue Distribution

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.