The influence of age and approaching death on the course of nondopaminergic symptoms in Parkinson's disease

Parkinsonism & Related Disorders
Stephanie M van RoodenJacobus J van Hilten

Abstract

The influence of approaching death in addition to age and their interaction on the course of a broad spectrum of nondopaminergic features in Parkinson's disease (PD) has not been well studied. This study addresses this issue in a prospectively designed study. During five years, the severity of axial symptoms, cognitive impairment, psychotic symptoms, autonomic dysfunction, depressive symptoms, and daytime sleepiness was annually evaluated in PD patients. For each domain a linear mixed-effect model was used to examine changes during follow-up and relations with age and death. Of 378 included patients, 43 died during follow-up. Higher age was associated with increased severity of all nondopaminergic features except depression, and with a higher rate of progression of axial symptoms and cognitive impairment. Patients who died during follow-up had a higher severity of all nondopaminergic features except autonomic dysfunction, and a higher rate of progression of axial symptoms, cognitive impairment, and psychotic symptoms, compared to patients who survived. This study shows that the severity of most nondopaminergic features and the progression rate of axial and psychotic symptoms and cognitive impairment increase before PD patients ...Continue Reading

References

Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Apr 6, 1999·Archives of Neurology·E D LouisK Marder
Jun 27, 2003·Psychology and Aging·Brent J SmallLars Bäckman
Dec 15, 2004·Archives of Neurology·Dag AarslandPer Kragh-Sørensen
May 31, 2007·Brain : a Journal of Neurology·C H Williams-GrayR A Barker
Jun 26, 2007·Brain : a Journal of Neurology·P A KempsterA J Lees
Feb 13, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·S M van RoodenJ J van Hilten
Oct 9, 2009·Brain : a Journal of Neurology·Caroline H Williams-GrayRoger A Barker
Jan 1, 2010·Journal of Geriatric Psychiatry and Neurology·Oliver RiedelUNKNOWN GEPAD Study Group
Jan 7, 2010·Age and Ageing·John V Hindle
Apr 8, 2010·Brain : a Journal of Neurology·Peter A KempsterAndrew J Lees
Mar 15, 2011·Antioxidants & Redox Signaling·Maxx P HorowitzPier G Mastroberardino
May 23, 2012·Psychology and Aging·Robert S WilsonDavid A Bennett
Jun 30, 2012·Acta Neuropathologica·Darius Ebrahimi-FakhariPamela J McLean
May 25, 2013·The Gerontologist·Denis Gerstorf, Nilam Ram
Jun 27, 2013·Annals of Neurology·Patricia A BoyleDavid A Bennett

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Citations

Jun 2, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Sheng LuoChristopher G Goetz
May 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Chiara MilanesePier G Mastroberardino
Apr 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Maria Fiorella ContarinoJacobus J van Hilten
Dec 29, 2016·Acta neurologica Belgica·Svetlana TomicSanja Misevic
Mar 16, 2019·Journal of the American Medical Directors Association·Alice LaudisioGiuseppe Zuccalà

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