The influence of age and gender on niacin skin test results - implications for the use as a biochemical marker in schizophrenia

Journal of Psychiatric Research
Stefan SmesnyHeinrich Sauer

Abstract

Investigation of abnormal skin response to niacin (vitamin B3) stimulation has gained increasing interest in schizophrenia research during last years. However, current efforts to implement niacin tests in routine diagnostics are jeopardised by wide inter-individual variations of skin response. We investigated age and gender as potential factors of influence on niacin sensitivity in 117 healthy subjects (63 male, 54 female). Niacin was applied in three dilution steps (0.1, 0.01, 0.001 M) onto the inner forearm skin. Skin reaction was assessed in three minute intervals over 15 min using optical reflection spectroscopy. Males displayed a significantly weaker flush response than females. The rate of non-responders at the lowest concentration was about twice as high in men than women. Significant negative correlations between age and niacin sensitivity were revealed for both sexes. Age and gender considerably influence niacin sensitivity, possibly due to the effects of sex hormones on vasomotor function and prostaglandin metabolism. Consideration of gender and age is strongly recommended for further clinical niacin studies.

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Citations

May 12, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S SmesnyH Sauer
May 17, 2012·Schizophrenia Bulletin·Stefan SmesnyJoachim W Fluhr
Sep 26, 2008·BMC Research Notes·Brian M Ross, Martin Katzman
Aug 23, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Peter D Drummond, Daniel Lazaroo
Feb 2, 2010·Journal of Affective Disorders·Stefan SmesnyHeinrich Sauer
Jan 3, 2009·Neurobiology of Disease·Stephen J WoodChristos Pantelis
Sep 25, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E CyhlarovaA J Richardson
Jul 14, 2006·Psychiatry Research·Linda Bosveld-van HaandelRobert J van den Bosch
Apr 8, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B M NilssonF-A Wiesel
Nov 14, 2013·The Australian and New Zealand Journal of Psychiatry·Matthew SunderlandTim Slade
Jan 10, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Terrie E MoffittEssi Viding
Apr 6, 2006·Molecular Psychiatry·M H LawG E Berger
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefan SmesnyHeinrich Sauer

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