The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens

Avian Pathology : Journal of the W.V.P.A
S De BoeverS Croubels

Abstract

Our objective was to create a standardized and reproducible inflammation model in chickens in order to study the pharmacodynamics of several anti-pyretic and anti-inflammatory drugs. We studied the influence of age and repeated lipopolysaccharide (LPS) administration on body temperature and the correlation of this with concentrations of interleukin-6 and IgM antibodies against LPS in plasma of chickens. Three-week-old and 5-week-old broilers were injected intravenously with LPS from Escherichia coli O127: B8 at a dose of 1 mg/kg. LPS administration was repeated after 2 or 7 days. After the first dose of LPS, the body temperature was initially decreased below normal and then later increased above normal. The second dose of LPS reduced the level of hypothermia and the duration of the febrile phase. Three-week-old birds responded to LPS with a higher maximum body temperature and a greater area under the body temperature versus time curve than 5-week-old chickens (P<0.05). Interleukin-6 reached its highest concentration 3 h after LPS administration and returned to baseline levels after 9 h. A second dose of LPS resulted in a significantly lower peak in interleukin-6. Significant higher levels of antibodies against LPS could be dete...Continue Reading

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Citations

Nov 20, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·David A GrayShane K Maloney
Nov 26, 2009·Avian Pathology : Journal of the W.V.P.A·S De BoeverP De Backer
Apr 15, 2010·Avian Pathology : Journal of the W.V.P.A·S De BoeverE Meyer
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandre A SteinerAndrej A Romanovsky
Jan 27, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·G CasasoleJ Rutkowska
Mar 10, 2016·Avian Diseases·Shawkat A M'SadeqRobert A Swick
Jan 24, 2009·Journal of Veterinary Pharmacology and Therapeutics·S De BoeverS Croubels
Sep 23, 2014·International Journal of Biological Macromolecules·Lei LiuXiaojun Yang
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Manette MaraisDavid A Gray
Jun 26, 2020·Frontiers in Immunology·Kristen A ByrneJodi L McGill
Jan 22, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Niklas GrabbeJoachim Roth

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