PMID: 9193898May 1, 1997Paper

The influence of age and some inducers on UDP-glucuronyltransferase activity

Experimental Gerontology
A PlewkaD Plewka

Abstract

UDP-glucuronyltransferase (UDP-GT) activity was examined in male Wistar rats aged 0.5, 1, 2, 4, 8, 12, 20, and 28 months. The rats were treated with phenobarbital (75 mg/kg, 72 and 48 h before death), beta-naphthoflavone or dexamethasone (40 mg/kg and 20 mg/kg, respectively, for three days before death). Prior to decapitation the rats were fasted for 12 h. Hepatic microsomes were prepared according to the method of Dallner. UDP-GT activity was determined by the method of Burchell and Weatherill. p-Nitrophenol was used as an aglucone. UDP-GT activity decreased rapidly in the control rats aged from two weeks to four months. In the older control rats the activity tended to increase. Two-week-old rats treated with phenobarbital showed a slightly increased UDP-GT activity. In the older animals (up to one year) UDP-GT activity increased to 150% of the control value and stayed at this level in the remaining age groups. beta-Naphthoflavone was a more potent inducer of UDP-GT than phenobarbital. The activity of beta-naphthoflavone-induced UDP-GT was low in the youngest rats. It was about 180% in two-month-old rats and reached 260% of the control value in eight-month-old rats. Although the activity decreased in the older rats, it still e...Continue Reading

References

Oct 2, 1975·The New England Journal of Medicine·D J Greenblatt, J Kock-Weser
Mar 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·L A BengocheaA Lemberg
Apr 1, 1992·Biochemical Pharmacology·D Zakim, A J Dannenberg
Jun 12, 1992·Biochimica Et Biophysica Acta·A J DannenbergS Scarlata
Jul 22, 1992·Biochemical Pharmacology·A J Dannenberg, E K Yang
May 24, 1991·Biochimica Et Biophysica Acta·L E RikansC D Snowden
Oct 1, 1990·Clinical Pharmacology and Therapeutics·D L SchmuckerP Kremers
Oct 1, 1990·Biochemical Pharmacology·C M HuntG M Stave
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J ThomassinG Siest
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J A BoutinG Siest
May 1, 1987·The Biochemical Journal·J E LeakeyB Burchell
Jan 1, 1988·Gerontology·H Martin, R Martin
Aug 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K IwasakiH Noguchi
Nov 1, 1985·Biochemical Pharmacology·S FujitaK Kitani
May 30, 1970·Lancet·J M HansenH Laursen
Sep 1, 1980·Mechanisms of Ageing and Development·D Hegner
Jul 1, 1981·Archives of Biochemistry and Biophysics·R H Tukey, T R Tephly
Jan 1, 1981·Methods in Enzymology·B Burchell, P Weatherill
Mar 1, 1982·Journal of the American Geriatrics Society·R F Vestal
Jun 1, 1981·Mechanisms of Ageing and Development·R S SohalE R Biehl
Jan 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·G B OuviñaL A Bengochea
Sep 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B AntoineG Siest
Mar 29, 1994·Biochemical Pharmacology·M G LuquitaA D Mottino

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Citations

Oct 18, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C Viollon-AbadieL Richert
Nov 16, 2007·Nutrition and Cancer·Misty R Saracino, Johanna W Lampe

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