The influence of age of pH regulation in hippocampal slices before, during, and after anoxia

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
E L Roberts, C P Chih

Abstract

Changes in intracellular and extracellular pH may influence the vulnerability of brain tissue to anoxic or ischemic damage. In the present study, we investigated whether the increased vulnerability of aged brain tissue to anoxic damage is associated with age-related alterations in pH regulation. We obtained evidence for altered pH regulation by measuring concurrent changes in intracellular and extracellular pH before, during, and after anoxia in hippocampal slices from young adult (6-8 months old) and aged (24-27 months old) rats. We found indications of impaired pH regulation in aged hippocampal slices (a) before anoxia, as seen in a lower resting intracellular pH, (b) during anoxia, as seen in a slower decline in extracellular pH, and (c) during recovery after anoxia, as seen in a slower rate of recovery of intracellular pH. Age-related changes in pH regulation may contribute to the faster onset of anoxic depolarization in aged brain tissue during anoxia.

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Citations

Feb 10, 1999·Experimental Gerontology·E SykováZ Simonová
Jul 1, 2008·Oxidative Medicine and Cellular Longevity·Kenneth MaieseJinling Hou
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kenneth MaieseYan Chen Shang
Feb 26, 2004·Experimental Neurology·Zhongmin XiangPeter J Bergold
Jul 21, 1999·Journal of Neurobiology·A M VincentK Maiese
Apr 27, 2002·Journal of Neurophysiology·Claire Sheldon, John Church
Nov 5, 2016·Journal of Neuroinflammation·Anna A TyrtyshnaiaAlexander M Kleschevnikov
Sep 8, 2001·American Journal of Physiology. Cell Physiology·H YaoG G Haddad
Feb 2, 1999·Experimental Cell Research·A M Vincent, K Maiese
Mar 4, 2008·Pharmacology & Therapeutics·Kenneth MaieseYan Chen Shang
Mar 18, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kenneth Maiese
Apr 9, 2008·Progress in Neurobiology·Kenneth MaieseYan Chen Shang

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