The influence of age on intestinal dipeptidyl peptidase IV (DPP IV/CD26), disaccharidases, and alkaline phosphatase enzyme activity in C57BL/6 mice

Experimental Aging Research
Dijana DetelJadranka Varljen

Abstract

The objective of this study was to determine and describe the age-related changes in intestinal brush border membrane enzyme activities that occur in C57Bl/6 mice. Specifically, jejunal, duodenal, and ileal dipeptidyl peptidase IV/CD26, disaccharidase (lactase, sucrase, and maltase), and alkaline phosphatase activities were determined. A significant correlation between analyzed intestinal brush border membrane enzyme activities and animal age was found. Our study revealed that intestinal dipeptidyl peptidase IV/CD26, lactase, sucrase, maltase, and alkaline phosphatase activities decline significantly with age (p < .05). Nevertheless, the horizontal (duodenum to ileum) enzyme activity patterns are not affected by age.

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Citations

Mar 28, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D F PinheiroM L M Vicentini-Paulino
Jan 6, 2012·American Journal of Alzheimer's Disease and Other Dementias·Khanh vinh quoc Lu'o'ng, Lan Thi Hoang Nguyen
Jan 27, 2009·Journal of Cellular Physiology·Ainslie L K Derrick RobertsSharon Byers
Jul 28, 2016·Journal of Developmental Origins of Health and Disease·H ShojiT Shimizu
Aug 1, 2012·Bioprocess and Biosystems Engineering·Ozlem Ustün, Gaye Ongen
Mar 28, 2020·JCI Insight·Florian KühnRichard A Hodin
May 5, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jose Manuel Ramos-RincónUNKNOWN SEMI-COVID-19 Network

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