PMID: 10360845Jun 9, 1999Paper

The influence of age on propofol pharmacodynamics

Anesthesiology
T W SchniderE J Youngs

Abstract

The authors studied the influence of age on the pharmacodynamics of propofol, including characterization of the relation between plasma concentration and the time course of drug effect. The authors evaluated healthy volunteers aged 25-81 yr. A bolus dose (2 mg/kg or 1 mg/kg in persons older than 65 yr) and an infusion (25, 50, 100, or 200 microg x kg(-1) x min(-1)) of the older or the new (containing EDTA) formulation of propofol were given on each of two different study days. The propofol concentration was determined in frequent arterial samples. The electroencephalogram (EEG) was used to measure drug effect. A statistical technique called semilinear canonical correlation was used to select components of the EEG power spectrum that correlated optimally with the effect-site concentration. The effect-site concentration was related to drug effect with a biphasic pharmacodynamic model. The plasma effect-site equilibration rate constant was estimated parametrically. Estimates of this rate constant were validated by comparing the predicted time of peak effect with the time of peak EEG effect. The probability of being asleep, as a function of age, was determined from steady state concentrations after 60 min of propofol infusion. Twen...Continue Reading

References

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Citations

Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mio ShinozakiToshimitsu Kitajima
Feb 16, 2006·Der Anaesthesist·H IhmsenF Bremer
Aug 19, 2007·Zeitschrift für Gerontologie und Geriatrie·H BurkhardtR Gladisch
Jan 6, 2012·Biomedical Microdevices·Chien-Chong HongPo-Hsiang Chang
Apr 24, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Marcus A BjörnssonUlrika S H Simonsson
Jul 17, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ngai LiuMarc Fischler
Dec 12, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Roberto CordellaGiovanni Broggi
Jun 18, 2005·Medical Engineering & Physics·Jiann-Shing ShiehChien-Chiang Liu
Aug 10, 2000·Anesthesiology Clinics of North America·S L Shafer
Jun 24, 2003·Best Practice & Research. Clinical Anaesthesiology·Mihai R Sadean, Peter S A Glass
Jun 24, 2003·Best Practice & Research. Clinical Anaesthesiology·Jaap Vuyk
Jun 13, 2009·British Journal of Anaesthesia·A R AbsalomM M R F Struys
Jan 21, 2010·British Journal of Anaesthesia·F H EngbersS Schraag
May 29, 2010·British Journal of Anaesthesia·D CuminA F Merry
Aug 17, 2010·British Journal of Anaesthesia·L I CortínezP Sepulveda
Jun 1, 2011·British Journal of Anaesthesia·M M R F StruysA R Absalom
Aug 16, 2011·British Journal of Anaesthesia·D L WilliamsK Leslie
Oct 27, 2004·Anesthesiology·Anthony G DoufasDaniel I Sessler
May 23, 2006·Critical Care Medicine·Bernard De Jonghe
Feb 28, 2001·Anesthesia and Analgesia·Y U AdachiT Satoh

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