The influence of age, smoking and hyperthyroidism on plasma propranolol steady state concentration

British Journal of Clinical Pharmacology
J FeelyI H Stevenson

Abstract

1 Plasma propranolol steady state concentration (Css) was determined during chronic dosage (160 mg/day) in 22 hyperthyroid patients (aged 16-75 years, 11 smokers, 11 non-smokers) and again following treatment when euthyroid. 2 There was a positive correlation between plasma propranolol Css and age in patients both when hyperthyroid (r = 0.74, P less than 0.01) and when euthyroid (r = 0.58, P less than 0.05). 3 Plasma propranolol Css in hyperthyroid patients were lower (P less than 0.05) in smokers than in non-smokers. 4 Following correction of hyperthyroidism there was a significant increase (P less than 0.01) in both the plasma propranolol Css and degree of plasma protein binding of propranolol. 5 Hyperthyroidism and smoking are known to increase the rate of drug metabolism and it is suggested that these variables may give rise to or accentuate an age related reduction in propranolol clearance.

References

Aug 1, 1979·Clinical Pharmacology and Therapeutics·R E VestalD G Shand
Mar 1, 1979·Clinical Pharmacokinetics·P A Routledge, D G Shand
Jul 1, 1979·Clinical Pharmacology and Therapeutics·A J WoodD G Shand
Jul 1, 1979·Clinical Pharmacology and Therapeutics·R E VestalG R Wilkinson
Oct 1, 1979·British Journal of Clinical Pharmacology·J FeelyI H Stevenson
Aug 1, 1978·British Journal of Clinical Pharmacology·J G Kelly, D G McDevitt
Dec 1, 1978·Clinical Pharmacology and Therapeutics·T WalleT E Gaffney
Feb 15, 1979·The New England Journal of Medicine·S RubenfeldP O Kohler
Jan 1, 1979·British Journal of Clinical Pharmacology·C M Castleden, C F George
Jan 1, 1976·Clinical Pharmacokinetics·J CrooksI H Stevenson
Jan 1, 1976·Clinical Pharmacokinetics·M Eichelbaum
Jul 1, 1977·The American Journal of Psychiatry·A NiesJ O Ives
Jun 1, 1977·British Journal of Clinical Pharmacology·D L BloxamP H Hutson
Oct 1, 1975·Clinical Pharmacology and Therapeutics·R E VestalR Andres
Feb 1, 1975·British Journal of Clinical Pharmacology·M J HayesA H Short
Feb 1, 1975·British Journal of Clinical Pharmacology·M J HayesA H Short
Jun 1, 1975·British Journal of Clinical Pharmacology·G W HoughtonM Leighton
Sep 1, 1974·The Medical Clinics of North America·D G Shand
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J FeelyJ Crooks
Aug 1, 1980·British Journal of Clinical Pharmacology·R E SchneiderM J Kendall

❮ Previous
Next ❯

Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·J FeelyI H Stevenson
Oct 1, 1980·European Journal of Clinical Pharmacology·O R NilssonL Tegler
Jan 1, 1984·European Journal of Clinical Pharmacology·R BendayanG J Caranasos
Jan 1, 1990·Pharmacology & Therapeutics·M Barry, J Feely
May 6, 1982·The New England Journal of Medicine·D J GreenblattR I Shader
Jul 13, 1985·British Medical Journal·A Breckenridge
Oct 1, 1990·Chest·W B Abrams
Jan 1, 1985·Journal of Hepatology·O F James
Jul 1, 1985·The Journal of Pharmacy and Pharmacology·K IwamotoH Sugiyama
Nov 1, 1985·Pharmacotherapy·F PucinoI L Silbergleit
Aug 3, 1989·The New England Journal of Medicine·S C MontamatR E Vestal
Dec 30, 2020·Journal of the American Heart Association·Xuejing SunJingjing Cai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

British Journal of Clinical Pharmacology
M A DonovanC A Kraft
European Journal of Clinical Pharmacology
A AroH Sundquist
The New England Journal of Medicine
T L Gross, W A Cook
British Journal of Anaesthesia
C T Dollery
© 2021 Meta ULC. All rights reserved