PMID: 15329208Aug 27, 2004Paper

The influence of alcohol on the liver sinusoids endothelial cell fenestrae of rats

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Bing-Yuan WangYan-Xue Cao

Abstract

To study the influence of alcohol on the liver sinusoids endothelial cell (LSEC) fenestrae of rats. Setting up the rat model of alcoholic liver disease by orogastric administration of alcohol, then kill the experimental and control groups of rats at the end of 4 weeks, 8 weeks and 12 weeks after alcohol feeding, and also at the end of another 12 weeks after balance foods feeding succeeding with alcohol feeding for 12 weeks. Staining the liver tissue by means of HE method and observing the successive change of LSEC fenestrae by transmission electron microscope. The normal LSEC was flat with nucleus and organelle arranged regularly. The distal cytoplasm displayed as lamina with many fenestrae, not accompanied by basement membrane (BM) formation under the endothelial cell. At the end of 4 weeks of alcohol feeding, fenestrae decreased at the partial distal LSEC cytoplasm, but no BM developed. At the end of 8 weeks, fenestrae decreased significantly, even disappeared, with the BM developed incompletely under the endothelial cell. Concomitantly, fibroblast with active function developed. At the end of 12 weeks, the changes became more obvious; the complete BM could even be seen. However, this kind of changes was mostly limited in the...Continue Reading

Related Concepts

Related Papers

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Qin ZhangMing-hui Yang
Hepatobiliary & Pancreatic Diseases International : HBPD INT
Bing-Yuan WangYan-Xue Cao
Liver International : Official Journal of the International Association for the Study of the Liver
Filip BraetPeter Frederik
© 2021 Meta ULC. All rights reserved