The influence of allogenic blood transfusion in patients having free-flap primary surgery for oral and oropharyngeal squamous cell carcinoma

British Journal of Cancer
T SzakmanyS N Rogers

Abstract

The influence of perioperative blood transfusion in oral and oropharyngeal squamous cell carcinoma remains uncertain. It is believed that blood transfusion downregulates the immune system and may have an influence on cancer recurrence and survival. In all, 559 consecutive patients undergoing primary surgery for oral and oropharyngeal squamous cell carcinoma between 1992 and 2002 were included in this study. Known prognostic variables along with transfusion details were obtained from head and neck cancer and blood transfusion service databases, respectively. Adjusting for relevant prognostic factors in Cox regression, the hazard ratio for patients having 3 or more transfused units relative to those not transfused was 1.52 (95% confidence interval (CI) 0.93-2.47) for disease-specific and 1.52 (95% CI 1.05-2.22) for overall mortality. Blood transfusion of 3 or more units might confer a worse prognosis in patients undergoing primary surgery for oral and oropharyngeal squamous cell carcinoma. Therefore, every effort should be made to limit the amount of blood transfused to the minimum requirement.

References

Oct 12, 1978·The New England Journal of Medicine·G Opelz, P I Terasaki
Sep 1, 1992·The Annals of Otology, Rhinology, and Laryngology·A L WoolleyJ L Goldenberg
Jan 11, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P von DoerstenR L Hilsinger
Jun 1, 1991·Clinical Otolaryngology and Allied Sciences·T Alun-JonesJ Hill
Mar 1, 1990·Archives of Otolaryngology--head & Neck Surgery·K R Jones, M C Weissler
May 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S A RosenbergR Wesley
Aug 15, 1981·Lancet·C L Gantt
Jul 1, 1994·Archives of Otolaryngology--head & Neck Surgery·D E SchullerG Laramore
Dec 24, 1997·Southern Medical Journal·E M SturgisR H Miller
Aug 17, 1999·Archives of Otolaryngology--head & Neck Surgery·M S MoirD J Terris
May 17, 2001·The European Journal of Surgery = Acta Chirurgica·K WertherUNKNOWN Danish RANX05 Colorectal Cancer Study Group
Jun 1, 2001·The British Journal of Oral & Maxillofacial Surgery·C LeitnerP Magennis
Jun 25, 2002·The Annals of Thoracic Surgery·Stephen M LangleyDavid F Weeden
Feb 13, 2003·Archives of Otolaryngology--head & Neck Surgery·Karina de Cássia Braga RibeiroMaria do Rosário Dias de Oliveira Latorre
Feb 11, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·G Macdonald, D C Hurman
Jun 16, 2004·Critical Care : the Official Journal of the Critical Care Forum·E Patchen Dellinger, Daniel A Anaya

❮ Previous
Next ❯

Citations

Aug 31, 2010·British Journal of Anaesthesia·A Ashworth, A A Klein
Sep 16, 2015·The Laryngoscope·Sara Abu-GhanemMoshe Yehuda
Mar 16, 2017·The Laryngoscope·Nicholas E Wirtz, Samir S Khariwala
Feb 23, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sarah R RossmillerMark K Wax
Jan 30, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sidharth V PuramDaniel G Deschler
Mar 24, 2016·Cancer Growth and Metastasis·Hadi A GoubranThierry Burnouf
Oct 5, 2011·The Oncologist·Dirk Schrijvers
Mar 12, 2016·The Journal of Craniofacial Surgery·George Richard Francis MurphyAbhilash Jain
Nov 2, 2017·Journal of Dental Anesthesia and Pain Medicine·So-Young ParkMyong-Hwan Karm
Sep 7, 2020·Journal of Reconstructive Microsurgery·Efstathios KaramanosHoward T Wang
Dec 26, 2019·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Florian D GrillVojta Kadera
Mar 7, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Leonard Simon BrandenburgMichael Andreas Ermer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
S WeedenEuropean Osteosarcoma Intergroup
Annals of the Royal College of Surgeons of England
S Cheslyn-CurtisR K Phillips
The American Journal of Cardiology
Sing-Chien YapCandice K Silversides
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ding ChenWan-Chun Wang
© 2021 Meta ULC. All rights reserved