The influence of amino acid source on the stability of ascorbic acid in TPN mixtures

Nutrition
M C KearneyG Hardy

Abstract

This study was undertaken to investigate the stability of ascorbic acid and its primary degradation product, dehydroascorbic acid, in total parenteral nutrition (TPN) mixtures. The influence of the type of bag and the commercial source of amino acid on ascorbate degradation was examined, using a stability-indicating high-pressure liquid chromatography (HPLC) method. Ascorbic acid was most stable in multilayered bags, compared with ethylvinyl acetate (EVA) bags. Results indicated that, in multilayered bags, the initial rapid ascorbic acid degradation was greatest in TPN mixtures containing amino acid infusions without reducing activity. In contrast, degradation in TPN mixtures containing amino acids with reducing compounds (Vamin 14 and Freamine III 8.5%) was less than 10% of the added amount. Dehydroascorbic acid degraded approximately in parallel with ascorbic acid, and it contributed to the total available ascorbate activity. The addition of air to TPN mixtures in multilayered bags caused accelerated degradation of both ascorbic acid and dehydroascorbic acid. It is concluded that TPN mixtures compounded in multilayered bags can be safely assigned extended shelf lives, especially if compounded using an amino acid with reducing...Continue Reading

References

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Citations

Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Christophe GellisJean Chopineau
May 30, 2001·Journal of Pharmaceutical and Biomedical Analysis·E GibbonsG Hardy
Jul 13, 2001·The Journal of Nutritional Biochemistry·C J. Dufresne, E R. Farnworth
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M C Allwood, H Martin
Oct 14, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M C Allwood, H J Martin
Mar 18, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Yves M DupertuisClaude Pichard
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M C AllwoodM Maunder
Oct 15, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Gil HardyPatrick A Ball
Feb 21, 2008·Journal of Agricultural and Food Chemistry·Keum-Il Jang, Hyeon Gyu Lee
Nov 18, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph I BoullataUNKNOWN ASPEN Parenteral Nutrition Safety Committee

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