The influence of an antitumor lipid - erucylphosphocholine - on artificial lipid raft system modeled as Langmuir monolayer

Molecular Membrane Biology
Anita WnętrzakP Dynarowicz-Łatka

Abstract

Outer layer of cellular membrane contains ordered domains enriched in cholesterol and sphingolipids, called 'lipid rafts', which play various biological roles, i.e., are involved in the induction of cell death by apoptosis. Recent studies have shown that these domains may constitute binding sites for selected drugs. For example alkylphosphocholines (APCs), which are new-generation antitumor agents characterized by high selectivity and broad spectrum of activity, are known to have their molecular targets located at cellular membrane and their selective accumulation in tumor cells has been hypothesized to be linked with the alternation of biophysical properties of lipid rafts. To get a deeper insight into this issue, interactions between representative APC: erucylphosphocholine, and artificial lipid raft system, modeled as Langmuir monolayer (composed of cholesterol and sphingomyelin mixed in 1:2 proportion) were investigated. The Langmuir monolayer experiments, based on recording surface pressure-area isotherms, were complemented with Brewster angle microscopy results, which enabled direct visualization of the monolayers structure. In addition, the investigated monolayers were transferred onto solid supports and studied with AFM...Continue Reading

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Citations

May 28, 2020·Biomolecules·Rumiana TzonevaSalvatore Chiantia
Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paulina LaszukAneta D Petelska
Jul 28, 2020·Journal of Bioenergetics and Biomembranes·Wojciech SzlasaJulita Kulbacka
May 6, 2021·International Journal of Molecular Sciences·Paulina Laszuk, Aneta D Petelska

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