The influence of anterior cerebral artery flow diversion measured by transcranial Doppler on acute infarct volume and clinical outcome in anterior circulation stroke

International Journal of Stroke : Official Journal of the International Stroke Society
Hossein ZareieChristopher Levi

Abstract

Anterior cerebral artery flow diversion, measured by transcranial Doppler ultrasound, is correlated with leptomeningeal collateral flow on digital subtraction angiography in the setting of middle cerebral artery occlusion. We aimed to assess the influence of flow diversion as a marker of leptomeningeal collateralization on infarct size and penumbral volume. We assessed consecutive patients presenting within six-hours of ischaemic stroke. Anterior cerebral artery flow diversion, defined as ipsilateral mean velocity of at least 30% greater than the contralateral artery, was used as the Doppler index of leptomeningeal collateralization. Multivariable regression analysis was performed to assess the impact of anterior cerebral artery flow diversion, controlling for other important clinical variables. Leptomeningeal collateralization was also graded on computed tomography angiography. Infarct core and penumbral volumes were defined using computed tomography perfusion thresholds of cerebral blood volume and mean transit time. Infarct volume, reperfusion, and vessel status were measured at 24 h using magnetic resonance techniques. Fifty-three patients qualified for analysis. Anterior cerebral artery flow diversion was associated with g...Continue Reading

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Citations

Apr 23, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Siva Seeta RamaiahBernard Yan
Aug 8, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Maher SaqqurAshfaq Shuaib
Jun 27, 2020·PloS One·Jakub Grzegorz AdamczykDariusz Boguszewski

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