PMID: 7019431Jul 1, 1981Paper

The influence of anti-zona and anti-sperm antibodies on sperm--egg interactions

Journal of Reproduction and Fertility
R J AitkenA A Templeton

Abstract

Anti-zona antibodies are effective inhibitors of fertilization in vitro and, regardless of whether passive or active immunization techniques are used, in vivo. Antibodies raised against unfractionated zona pellucida antigens are chiefly directed against a group of carbohydrate-rich components localized on the outer surface of the zona. The interaction of anti-zona antibodies with these sites induces the formation of a surface precipitate which occludes the sperm binding sites by a process of steric hindrance, and stabilizes the zona structure against digestion by the proteolytic enzymes of the sperm head. Active immunization studies indicate that the long-term induction of infertility without adverse side effects is feasible in both laboratory rodents and primates when the zona pellucida is used as a target. Anti-sperm antibodies also exhibit a capacity for inhibiting fertilization in vivo and in vitro. To determine the most appropriate detection method to screen patients for anti-sperm antibodies several homologous and heterologous antisera were analysed by 5 different agglutination and immobilization techniques and then compared for their ability to inhibit the fertilizing capacity of human spermatozoa using the zona-free ham...Continue Reading

Citations

Oct 1, 1986·Journal of in Vitro Fertilization and Embryo Transfer : IVF·S L MandelbaumA H DeCherney
Jun 1, 1982·American Journal of Reproductive Immunology : AJRI·J DietlL Mettler
Jan 1, 1985·Annals of the New York Academy of Sciences·J J Suominen, V Nikkanen
Jan 1, 1993·Molecular Reproduction and Development·M L AmielJ Testart
Feb 1, 1984·International Journal of Andrology·M R Prasad
Mar 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·J DietlL Mettler
May 1, 1987·Die Naturwissenschaften·J Dietl
Oct 22, 2020·Seminars in Reproductive Medicine·Robert John Aitken

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