PMID: 6027643Jul 1, 1967Paper

The influence of antibodies on immunologic responses. I. The effect on the response to particulate antigen in the rabbit

The Journal of Experimental Medicine
D S Pearlman

Abstract

The influence of antibody on antibody formation to particulate antigen was examined in the rabbit with special reference to the importance of immunoglobulin type, the amount and relative proportion of antigen and antibody involved, and the specificity of this influence. 19S as well as 7S antibody was shown to be an effective inhibitor of antibody formation, although there was some evidence that 7S antibody was the more efficient of the two in doing so. The inhibitory effect of antibody was found to be specific for homologous antigenic determinants. Both 19S and 7S antibody were also able to enhance antibody formation. In contrast to the suppressive phenomenon, however, enhancement appeared to be nonspecific since antibody reactive with homologous (sheep red blood cell) determinants could enhance the response not only to homologous determinants but to heterologous (dinitrobenzene) determinants conjugated to the red blood cells as well. Smaller amounts of antibody were needed to enhance than to suppress antibody formation, and suppression and enhancement depended to some extent on the amount of antigen as well as to the amount of antibody used. The enhancing and suppressing influence of antibody on antibody formation appeared to ...Continue Reading

References

Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Sep 1, 1963·Journal of Theoretical Biology·D W Talmage, D S Pearlman
May 1, 1956·The Journal of Infectious Diseases·D W TALMAGEW H TALIAFERRO
Jul 1, 1956·The Journal of Infectious Diseases·W H TALIAFERRO, D W TALMAGE
May 27, 1961·British Medical Journal·R FINNW KULKE
May 1, 1961·The Journal of Experimental Medicine·J W UHR, J B BAUMANN
May 1, 1961·The Journal of Experimental Medicine·J W UHR, J B BAUMANN
Oct 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·G TERRES, W WOLINS
Jul 24, 1964·Science·K SAHIAR, R S SCHWARTZ
Jun 1, 1965·The Journal of Experimental Medicine·G MOLLER, H WIGZELL
Jul 1, 1950·The Journal of Infectious Diseases·W H TALIAFERRO, L G TALIAFERRO

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Citations

Mar 1, 1984·Journal of Clinical Immunology·C WiesenhutterR F Ashman
Jul 1, 1968·The Journal of Experimental Medicine·C Henry, N K Jerne
Nov 1, 1970·The Journal of Experimental Medicine·W W Bullock, M B Rittenberg
May 1, 1971·The Journal of Experimental Medicine·C S PincusV Nussenzweig
Oct 1, 1971·The Journal of Experimental Medicine·R A McBride, L W Schierman
Jul 1, 1977·The Journal of Experimental Medicine·M A Berman, W O Weigle
Dec 1, 1971·British Journal of Haematology·H H GunsonP K Phillips
Oct 19, 1968·British Medical Journal·J C Woodrow, W T Donohoe
Sep 1, 1971·Journal of Medical Genetics·J Bradley, C J Elson
Aug 22, 2006·Scandinavian Journal of Immunology·F HjelmB Heyman
Dec 1, 1978·International Journal of Cancer. Journal International Du Cancer·R BillingJ Minowada
Jan 1, 1974·European Journal of Immunology·J H PlayfairL Hudson
Jul 19, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lidice BernardoAlan H Lazarus
Apr 1, 1985·European Journal of Immunology·G Möller
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony P MandersonChris R Parish
Dec 1, 1972·Infection and Immunity·H Okuyama, K Morikawa
Dec 1, 1974·Infection and Immunity·R G NavalkarL Levy
Sep 21, 1973·Science·D A RowleyH Cosenza

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