The influence of anticoagulant and antiagregant therapy during pregnancy on clinical characteristics and outcomes of periventricular hemorrhages in newborns

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
D D Gaynetdinova, L K Karimova

Abstract

To evaluate the characteristics of periventricular hemorrhages (PVH) in newborns of mothers receiving antiplatelet and anticoagulation therapy during pregnancy with hypercoagulation syndrome. One hundred and twelve newborns with PVH were evaluated: group 1 - 37 children, born after a pregnancy with hypercoagulation syndrome and antithrombotic therapy; group 2 - 55 children, born after a pregnancy without hypercoagulation syndrome and with preventive antithrombotic therapy; group 3 - 20 children, born after a pregnancy without hypercoagulation syndrome and without antithrombotic therapy. All newborns underwent clinical and neurologic examinations combined with assessment using special scales and intracranial ultrasound evaluation. Maternal anticoagulation therapy during pregnancy in groups I and 2 was associated with more severe condition of newborns with PVH (significantly prolonged artificial lung ventilation, more premature births, larger hemorrhage) compared to newborns in group 3. Follow-up of infants in groups I and 2 demonstrated a significantly slower progress of postural muscle tone, psychological and psychomotor development compared to infants in group 3. Hypercoagulation syndrome treatment during pregnancy significant...Continue Reading

References

Oct 13, 2012·Early Human Development·Andrew Whitelaw
Mar 6, 2013·JAMA Pediatrics·Allison H PayneUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jul 17, 2013·La Presse médicale·Céline ChauleurJean-Christophe Gris
Feb 20, 2015·Hematology·Saskia Middeldorp
Sep 19, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Andra H James
Jun 11, 2016·Stroke; a Journal of Cerebral Circulation·Sara KaffashianStéphanie Debette

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