The influence of antithyroid drugs and iodine on thyroid cell MHC class II antigen expression.

Clinical Endocrinology
T F DaviesM Platzer

Abstract

We have investigated the influence of antithyroid drugs (methimazole and propylthiouracil) and sodium iodide on the expression of major histocompatibility (MHC) class II antigen expression in human and rat thyroid cells. While methimazole and propylthiouracil significantly inhibited lectin-induced MHC class II (HLA-DR) antigen in crude human thyroid monolayer preparations these drugs had no influence on gamma-interferon induction of class II antigens in similar cell preparations. Hence, antithyroid drugs probably had a direct effect on thyroid monolayer T cells which are known to effect the lectin induction of MHC class II antigen via T-cell secretion of the cytokine, gamma-interferon (IF). Sodium iodide, similarly, had no direct influence on human thyroid cell MHC class II antigen expression induced by gamma-IF. However, iodide significantly inhibited the gamma-IF-induced expression of MHC class II antigens in a proliferating rat thyroid cell clone derived from FRTL-5 cells (clone 1B-6). In the rat thyroid cell clone this antagonistic action appeared to be exerted via inhibition of TSH-induced proliferation. These data add further support to the multifactorial nature of the profound immunosuppressive influence of antithyroid d...Continue Reading

References

Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·W A MacKenzieT F Davies
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·A P WeetmanA S Fauci
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·L A PiccininiT F Davies
Mar 21, 1987·British Medical Journal·R Hall, J H Lazarus
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·T F Davies
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·B E Belshaw, D V Becker
Dec 1, 1981·The Journal of Clinical Endocrinology and Metabolism·I Weiss, T F Davies
Aug 7, 1980·The New England Journal of Medicine·A M McGregorR Hall
Feb 1, 1984·The Journal of Clinical Investigation·T F DaviesM A Gerber

❮ Previous
Next ❯

Citations

Jun 22, 1999·Molecular and Cellular Endocrinology·K OheH Nawata
Jan 1, 1997·Journal of Ethnopharmacology·M M al-HarbiA H Shah
Jul 10, 2001·Thyroid : Official Journal of the American Thyroid Association·D E Zantut-WittmannJ Vassallo
Aug 30, 2007·Thyroid : Official Journal of the American Thyroid Association·Labrini PapanastasiouGeorge Mastorakos
Jul 24, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S NazarpourF Azizi
Jan 1, 1990·Nutrition Research Reviews·R J Ross, C R Buchanan
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·G KahalyG Hommel
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang D DaiGeorge Carayanniotis
Jan 1, 1992·International Reviews of Immunology·T R Brown, N Bagchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.