The influence of aquaporin-1 and microvessel density on ovarian carcinogenesis and ascites formation

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
J H YangW J Qi

Abstract

This study aimed at investigating aquaporin-1 (AQP1) distribution and expression in primary ovarian epithelial tumors, correlating with clinicopathologic variables and intratumoral microvessel density (IMD). The AQP1 expression and IMD in 105 cases with primary epithelial ovarian tumors were measured by semiquantitative immunohistochemical technique. AQP1 was located mainly in microvessels and small vessels but seldom in tumor cells. Expression of AQP1 and IMD in ovarian malignant tumors was significantly higher than that in borderline tumors (P= 0.000, P= 0.001, respectively), and that in borderline tumors was higher than in benign tumors (P= 0.008, P= 0.028, respectively). The expression of AQP1 in FIGO stage III-IV was more than that in stage I-II (P= 0.001), and cases with ascites volume greater than 1000 mL were more than cases with ascites volume less than 1000 mL (P= 0.000). There is a positively correlated relationship between expression of AQP1 and IMD (correlation coefficient 0.60, P= 0.000) and between expression of AQP1 and ascites volume (correlation coefficient 0.57, P= 0.000). These data implicate that high AQP1 expression may play an important role in the ovarian carcinogenesis, progression, and ascites formatio...Continue Reading

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Citations

Apr 4, 2014·Archives of Gynecology and Obstetrics·Chen XuejunYang Jianhua
Jan 19, 2016·Journal of Molecular Histology·Jiong MaXuejun Chen
Mar 4, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hong PanHe-Feng Huang
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Mar 22, 2014·Molecular and Clinical Oncology·Toru YoshidaKazuhiro Tsukada
Dec 25, 2016·Cancer Research·Joseph W WraggRoy Bicknell

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