PMID: 19946241Dec 1, 2009Paper

The influence of atorvastatin on parameters of inflammation and function of the left ventricle in patients with dilated cardiomyopathy

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Agata Bielecka-DabrowaMaciej Banach

Abstract

We assessed the influence of atorvastatin on selected indicators of an inflammation, function of the left ventricle and factors affecting the occurrence of rehospitalisation and mortality in patients with dilated cardiomyopathy (DCM). In a prospective, randomized study, 68 patients with DCM with LVEF <or=40% were divided into 2 groups: group A consisted of 41 patients who were administered atorvastatin 40 mg/daily for 2 months and 10 mg for the next 4 months; and B consisted of 27 patients who were treated without statin therapy. Initial tests included the measurement of TNF-alpha, IL-6, IL-10, and NT-proBNP concentrations, echocardiographic examination and the assessment of exercise capacity in the 6-min walk test (6-MWT). In group A (vs group B), IL-6 was significantly lower (p<0.0001) after 2 months of treatment with atorvastatin. IL-6 and TNFalpha decreased significantly in group A, compared with initial values (p=0.0017 and p=0.0087, respectively). NT-proBNP was also significantly reduced in the atorvastatin group (p=0.0004), while in the control group an increase of NT-proBNP was observed (p=0.0021). After 6 months, the number of patients in NYHA class III was significantly decreased (from 47% to 22.5%) in group A, and th...Continue Reading

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