The influence of ATP-binding cassette sub-family B member -1 (ABCB1) genetic polymorphisms on acute and chronic pain after intrathecal morphine for caesarean section: a prospective cohort study

International Journal of Obstetric Anesthesia
Alex T SiaEne Choo Tan

Abstract

Polymorphisms of the ATP-binding cassette sub-family B member -1 (ABCB1) gene that codes for P-glycoprotein could influence the efflux of morphine from the central nervous system affecting its analgesic action. We investigated the effect of ABCB1 gene polymorphisms on analgesia and the development of persistent pain in post caesarean patients. Women of Chinese descent who received spinal anaesthesia with intrathecal morphine for elective caesarean section were recruited. They were given intravenous morphine via a patient-controlled analgesia pump for postoperative analgesia. Blood samples were collected and analysed for the presence of C1236T, G2677T/A and C3435T single nucleotide polymorphisms of the ABCB1 gene. We primarily investigated the association between ABCB1 polymorphisms and the effect of morphine. In a postpartum phone survey of the subjects six months after surgery, the occurrence of persistent abdominal wound scar pain was established. We found no significant statistical difference in total morphine consumption, pain scores and side effects among the various genotypes. For C3435T polymorphism, there was a trend towards the association of the T allele and persistent pain for three months after surgery but this did ...Continue Reading

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Citations

Mar 13, 2013·International Journal of Obstetric Anesthesia·R LandauC Ortner
Jul 6, 2014·Best Practice & Research. Clinical Anaesthesiology·Andrea M Trescot
Sep 17, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Keith CandiottiMelvin Gitlin
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May 14, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Junjie YeoEne-Choo Tan
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Jan 16, 2021·Pharmacogenomics·Mongi Benjeddou, Ana M Peiró
Jan 19, 2021·Expert Opinion on Drug Metabolism & Toxicology·Henrike Bruckmueller, Ingolf Cascorbi
Apr 28, 2020·Anesthesiology Clinics·Albert Hyukjae Kwon, Pamela Flood
Apr 14, 2021·Journal of Clinical Pharmacology·Adaku Ofoegbu, Earl B Ettienne

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