PMID: 38309Jul 1, 1979

The influence of binder concentration on the bond formation of pharmaceutical granules

The Journal of Pharmacy and Pharmacology
N G Stanley-Wood, M S Shubair

Abstract

The formation of particle mucilage bonds with dicalcium phosphate dihydrate and starch mucilage binder reduces the B.E.T. nitrogen adsorption surface are from 196 to 0.96 m2 g-1. The maximum reduction (40%) of granule surface area at a binder concentration of 10% w/w corresponded to similar optima in friability, compressability and median granule size. Surface and pore-void structural analysis by mercury intrusion could not discriminate between pore-void sizes in the range 0.5-100 nm. Nitrogen adsorption measurements showed, however, that the microporous surface area decreased from 0.3 to 0.18 m2 g-1 as binder surface coverage increased over the concentration range 2 to 20% w/w starch mucilage.

References

Apr 1, 1993·The Journal of Pharmacy and Pharmacology·T Gebre-Mariam, A S Nikolayev
Apr 19, 2007·Evolution; International Journal of Organic Evolution·Lee Hsiang Liow

Citations

Apr 1, 1976·The Journal of Pharmacy and Pharmacology·H J Rogers, P S Lietman
Jul 1, 1976·Journal of Pharmaceutical Sciences·J T CarstensenM A Zoglio
Feb 1, 1975·Journal of Pharmaceutical Sciences·J B SchwartzE J Dehner
Dec 1, 1971·The Journal of Pharmacy and Pharmacology·D Ganderton, B M Hunter

Related Concepts

Drug Formulation Process
Pharmaceutical Vehicles
Keoflo
Adsorption
Calcium Phosphates
Starch
Pore
Microencapsulation
Mucilage - Polysaccharide
Calcium phosphate, dibasic, dihydrate

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