PMID: 3005792Feb 24, 1986Paper

The influence of Bordetella pertussis and its constituents on the beta-adrenergic receptor in the guinea pig respiratory system

Life Sciences
D Van Heuven-NolsenF P Nijkamp


In the present study, the effect of vaccination of guinea pigs with Bordetella pertussis was investigated, 4 days after treatment, on the cholinergic and beta-adrenergic receptor function in isolated tracheal spirals and the number of beta-adrenoceptor binding sites in guinea pig lung. It was found that B. pertussis caused an impairment in the beta-adrenoceptor function and a decrease in its number. Similar results were obtained with endotoxin. Leucocytosis promoting factor, however, was ineffective. These results indicate that endotoxin is the constituent responsible for the beta-adrenoceptor blocking effects of the bacterium. Also the combined whole cell diphtheria, B. pertussis and tetanus toxoid vaccine induced a beta-adrenoceptor blockade; the acellular vaccine was less effective. The results obtained with the B. pertussis vaccines are discussed in relation to the possible side-effects that sometimes occur after immunization of infants.


Jan 1, 1977·Infection and Immunity·R K Bergman, J J Munoz
May 1, 1977·European Journal of Immunology·H BesedovskyH Haas
Apr 30, 1976·Brain Research·J Van der GugtenD H Versteeg
Jan 21, 1984·Lancet·Y SatoH Fukumi
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A J SchreursF P Nijkamp
Jan 28, 1983·European Journal of Pharmacology·A J SchreursF P Nijkamp
Jan 1, 1982·Pharmacology & Therapeutics·A C Wardlaw, R Parton
Aug 5, 1983·Science·H BesedovskyC Honegger
Dec 24, 1982·European Journal of Pharmacology·D J De WildtF P Nijkamp

❮ Previous
Next ❯


Jan 1, 1989·European Journal of Pediatrics·D Reinhardt
Mar 14, 1989·European Journal of Pharmacology·D Van Heuven-NolsenF P Nijkamp
Oct 29, 1991·European Journal of Pharmacology·M O GucJ R Parratt
Jan 1, 1987·International Journal of Immunopharmacology·P A HenricksF P Nijkamp
Jan 1, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Cornelia E van MeijerenDick J de Wildt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.