The influence of BRCA2 mutation on localized prostate cancer

Nature Reviews. Urology
Renea A TaylorGail P Risbridger

Abstract

A key challenge in the management of localized prostate cancer is the identification of men with a high likelihood of progression to an advanced, incurable stage. Patients who harbour germline BRCA2 mutations have worse clinical outcomes than noncarriers when treated with surgery or radiotherapy. Insights from different disciplines have improved our understanding of why patients with BRCA2-mutant tumours have a high likelihood of failing on conventional management after diagnosis. Treatment-naive BRCA2-mutant tumours are defined by aggressive clinical and molecular features early in the disease course, and the genomic landscape of these BRCA2-mutant tumours is characterized by a unique molecular profile and higher genomic instability than noncarrier tumours. Moreover, BRCA2-mutant tumours commonly show the concurrent presence of the intraductal carcinoma of the prostate (IDCP) pathology, a poor prognostic indicator. Subclonal analyses have revealed that IDCP and invasive adenocarcinoma in BRCA2-mutant tumours can arise from the same ancestral clone, implying that a temporal evolutionary trajectory exists. Finally, functional studies have shown that BRCA2-mutant tumours can harbour a subpopulation of cancer cells that can tolera...Continue Reading

References

Sep 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Charles C Guo, Jonathan I Epstein
Dec 7, 2006·Journal of the National Cancer Institute·Harvey A RischSteven A Narod
Feb 11, 2011·Nature·Michael F BergerLevi A Garraway
Nov 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer A LockeRobert G Bristow
Mar 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Van der KwastM Bolla
May 23, 2012·Nature Genetics·Christopher E BarbieriLevi A Garraway
Nov 20, 2012·European Urology·Meelan BulMonique J Roobol
Dec 19, 2012·Nature Reviews. Urology·Monique J Roobol, Sigrid V Carlsson
Apr 6, 2013·Nature Protocols·Mitchell G LawrenceGail P Risbridger
Apr 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena CastroRosalind Eeles
Apr 30, 2013·Cell·Sylvan C BacaLevi A Garraway
May 4, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Dominique TrudelTheo van der Kwast
May 31, 2013·Science Translational Medicine·Roxanne ToivanenGail P Risbridger
Jul 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Haley HieronymusCharles L Sawyers
Sep 4, 2014·The New England Journal of Medicine·Emmanuel S AntonarakisJun Luo
May 23, 2015·Cell·Dan RobinsonArul M Chinnaiyan
May 26, 2015·Nature Genetics·Paul C BoutrosRobert G Bristow
Jun 5, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GillessenB Tombal
Jun 16, 2015·Lancet·Gerhardt AttardJohann S de Bono
Jul 15, 2015·European Urology·Jonathan I EpsteinEric A Klein
Sep 9, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E CastroUNKNOWN UKGPCS, EMBRACE and IMPACT studies
Oct 29, 2015·The New England Journal of Medicine·Joaquin MateoJohann S de Bono
Nov 7, 2015·Cell·UNKNOWN Cancer Genome Atlas Research Network
Jan 9, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Masashi KatoMomokazu Gotoh
Jan 19, 2016·Nature Reviews. Cancer·Christopher J Lord, Alan Ashworth
Jun 29, 2016·Nature Communications·Yunee KimThomas Kislinger
Jul 20, 2016·The New England Journal of Medicine·Colin C PritchardPeter S Nelson
Nov 26, 2016·Epigenomics·Haiyang GuoHousheng Hansen He
Jan 10, 2017·Nature Communications·Renea A TaylorRobert G Bristow
Jan 10, 2017·Nature·Michael FraserPaul C Boutros
Jun 10, 2017·Transcription·Fu Y Chua, Brian D Adams

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Citations

Feb 8, 2020·Genes & Development·Dea Slade
Oct 17, 2019·Nature Reviews. Urology·Louise Stone
Feb 13, 2020·Nature Reviews. Urology·Annette Fenner
May 3, 2020·Nature Reviews. Urology·Yiannis PhilippouRichard J Bryant
Jan 17, 2021·Pharmaceuticals·Xiaonan Zhang, Tobias Sjöblom
Mar 17, 2021·Prostate Cancer and Prostatic Diseases·Minh-Phuong Huynh-LeUNKNOWN PRACTICAL Consortium
Aug 10, 2021·Lancet·Shahneen SandhuScott G Williams

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Methods Mentioned

BETA
xenograft
biopsy
single-cell sequencing
transgenic

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