The influence of breathing motion on intensity modulated radiotherapy in the step-and-shoot technique: phantom measurements for irradiation of superficial target volumes

Physics in Medicine and Biology
Christoph ThilmannJürgen Debus

Abstract

For intensity modulated radiotherapy (IMRT) of deep-seated tumours, dosimetric variations of the original static dose profiles due to breathing motion can be primarily considered as blurring effects known from conventional radiotherapy. The purpose of this dosimetric study was to clarify whether these results are transferable to superficial targets and to quantify the additional effect of fractionation. A solid polystyrene phantom and an anthropomorphic phantom were used for film and ion chamber dose measurements. The phantoms were installed on an electric driven device and moved with a frequency of 6 or 12 cycles per minute and an amplitude of 4 mm or 10 mm. A split beam geometry of two adjacent asymmetric fields and an IMRT treatment plan with 12 fields for irradiation of the breast were investigated. For the split beam geometry the dose modifications due to unintended superposition of partial fields were reduced by fractionation and completely smoothed out after 20 fractions. IMRT applied to the moving phantom led to a more homogeneous dose distribution compared to the static phantom. The standard deviation of the target dose which is a measure of the dose homogeneity was 10.3 cGy for the static phantom and 7.7 cGy for a 10 ...Continue Reading

References

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Citations

Apr 30, 2009·Australasian Physical & Engineering Sciences in Medicine·A KellyP Metcalfe
Nov 26, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Max DaheleYee C Ung
Nov 26, 2009·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Dimitris N MihailidisPelagia Tomara
Aug 16, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eric D Ehler, Wolfgang A Tomé
Sep 23, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sarah QuirkWendy L Smith
Feb 7, 2007·Medical Physics·Rojano KashaniJames Balter
Sep 22, 2006·Current Opinion in Oncology·Erik Van Limbergen, Caroline Weltens
Jun 18, 2009·Physics in Medicine and Biology·Eric D Ehler, Wolfgang A Tomé
May 14, 2008·Technology in Cancer Research & Treatment·Taesoo SongJae Ho Cho

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