Abstract
In a short-time model of endotoxin-induced (lipopolysaccharide from Escherichia coli, 120 micrograms kg-1 i.v.) hypercoagulability in rabbits, the therapeutic effects of C1-esterase inhibitor (C1I) substitution (bolus 400 U kg-1 i.v. followed by continuous infusion of 400 U kg-1 4 h-1 i.v.) were studied. When compared to endotoxin-challenged untreated animals, C1I substitution significantly stabilized mean arterial pressure (p < 0.01), increased central venous oxygen saturation (p < 0.05), prevented the decrease of antithrombin III (p < 0.05), and reduced fibrin deposition in the microcirculation of the liver and the lungs to approximately 30% of that observed in the untreated animals (p < 0.01). Although C1I substitution did not reduce systemic procoagulant turnover, the improvement of blood pressure and blood flow and local inhibitory actions in the coagulation and complement cascade prevented fibrin deposition in the microcirculation of vital organs. This study supports the beneficial role of C1I substitution during early disseminated intravascular coagulation.
Citations
Aug 23, 2001·International Immunopharmacology·I G BosC E Hack
Jul 11, 2008·Expert Opinion on Biological Therapy·Diana WoutersSacha Zeerleder
Aug 5, 2008·Molecular Immunology·Alvin E DavisFengxin Lu
Jun 5, 2007·Immunobiology·Alvin E DavisDongxu Liu
Apr 13, 1999·Critical Care Medicine·R GieblerR Scherer
Feb 28, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Connie L DavisAlan H Wilkinson
Mar 19, 2019·Glia·Dorit FarfaraSidney Strickland
Oct 31, 2003·Intensive Care Medicine·Christian LehmannWolfgang J Kox
Nov 4, 2004·Blood·Dongxu LiuAlvin E Davis
Aug 10, 2000·Journal of Hypertension·T AbumiyaJ Ogata
Oct 5, 2001·Expert Opinion on Pharmacotherapy·M Kirschfink, T E Mollnes
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dongxu LiuAlvin E Davis
Jun 2, 2020·Expert Review of Clinical Pharmacology·Kevin Burnham, Justin P Reinert
Oct 21, 2005·Chest·Sacha ZeerlederWalter A Wuillemin