PMID: 6539287May 1, 1984Paper

The influence of caffeine on tumour incidence in Sprague-Dawley rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
U MohrK Morgareidge

Abstract

Food-grade natural caffeine was given in the drinking-water (available ad lib.) to barrier-maintained specified-pathogen free Sprague-Dawley rats for 2 yr. Groups of 50 animals per sex received levels of 200, 430, 930 and 2000 mg caffeine/litre, while two control groups, each of 50 animals per sex, received plain water. No unusual tumours or sites of origin for neoplastic growth were found in any animal receiving caffeine. Neoplasms found in various organs showed incidences not exceeding those seen in controls. Thus, exposure to caffeine for 2 yr did not enhance or induce neoplasia in the Sprague-Dawley rats.

References

Aug 1, 1977·Food and Cosmetics Toxicology·H P WürznerH Luginbühl
Jul 1, 1977·Life Sciences·A R BauerJ D Mason
May 13, 1972·Lancet·B R Zeitlin
Jan 1, 1980·Drug and Chemical Toxicology·A W Macklin, R J Szot
Jun 25, 1981·The New England Journal of Medicine
Dec 1, 1981·International Journal of Cancer. Journal International Du Cancer·D TrichopoulosA Polychronopoulou
Mar 12, 1981·The New England Journal of Medicine·B MacMahonG Nardi

❮ Previous
Next ❯

Citations

Dec 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R StalderH Luginbühl
Jan 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·X ShiA C Jain
Jan 11, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S M TarkaC A Shively
Feb 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W BartschU Mohr
Jan 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R HasegawaN Ito
Jan 10, 2003·Food Additives and Contaminants·P NawrotM Feeley
Oct 5, 2011·Mutation Research·Giovanni BrambillaAntonietta Martelli
Oct 3, 2009·The Journal of Toxicological Sciences·Izumi OgawaKoji Usuda
Jun 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J K Yeh, J F Aloia
Jul 15, 1985·International Journal of Cancer. Journal International Du Cancer·R HeilbronnH Zur Hausen
Nov 19, 2020·Food & Function·Sara Shojaei-ZarghaniSaber Azami-Aghdash

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.